Effect of Shengqing Jiangzhuo Fang on Glycolipid Metabolism in Monosodium L-Glutamate Rats

XIA Jia-nan; ZHANG De-qin; DU Juan; WEN Jing

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Effect of Shengqing Jiangzhuo Fang on Glycolipid Metabolism in Monosodium L-Glutamate Rats

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- Effect of Shengqing Jiangzhuo Fang on Glycolipid Metabolism in Monosodium L-Glutamate Rats
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 201-203(2013)
- 作者机构：
  
  天津中医药大学中医药研究院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]夏佳楠,张德芹,杜娟,文静.升清降浊方对谷氨酸钠肥胖模型大鼠骨骼肌糖脂代谢的影响[J].中国实验方剂学杂志,2013,19(09):201-203.

XIA Jia-nan, ZHANG De-qin, DU Juan, et al. Effect of Shengqing Jiangzhuo Fang on Glycolipid Metabolism in Monosodium L-Glutamate Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 201-203.
[1]夏佳楠,张德芹,杜娟,文静.升清降浊方对谷氨酸钠肥胖模型大鼠骨骼肌糖脂代谢的影响[J].中国实验方剂学杂志,2013,19(09):201-203. DOI：

XIA Jia-nan, ZHANG De-qin, DU Juan, et al. Effect of Shengqing Jiangzhuo Fang on Glycolipid Metabolism in Monosodium L-Glutamate Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 201-203. DOI：

摘要

目的:观察升清降浊方对皮下注射谷氨酸钠（MSG）大鼠骨骼肌的影响

以探索其改善胰岛素抵抗的作用机制。方法:新生大鼠皮下注射MSG并高脂诱导

制造胰岛素抵抗肥胖大鼠

选择48只MSG肥胖模型大鼠

雌雄各半。将大鼠随机分为6组:模型组

菲诺贝特100 mg.kg-1剂量组

罗格列酮5 mg.kg-1剂量组

升清降浊方6

1.5 g.kg-1剂量组;选正常鼠8只

雌雄各半做为正常对照组。给药50 d后

观察受试药物对MSG肥胖模型大鼠骨骼肌中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及糖元含量的影响。结果:升清降浊方对MSG肥胖模型大鼠骨骼肌糖脂代谢有明显改善作用

与模型组相比

给药组大鼠骨骼肌中TC

LDL-C及糖元含量明显降低

升清降浊方3个剂量组具有极显著性差异（P<0.01）;给药组骨骼肌中HDL-C含量明显升高

升清降浊方3 g.kg-1剂量组具有极显著性差异（P<0.01）。结论:升清降浊方能明显改善MSG大鼠骨骼肌组织中脂质和糖原含量。

Abstract

Objective:To observe the effects of Shengqing Jiangzhuo Fang（SQJZF） on skeletal muscle in monosodium L-glutamate（MSG） obese rats with insulin resistance.Method: The rat MSG-obese model was produced by giving neonatal rats subcutaneous injection of monosodium glutamate and induced with high-fat diet.Sixty MSG rats were divided into seven grous（4 male and 4 female per gtoup） randomly.the rosiglitazone group

the fenofibrate group

high dose

middle dose and low dose of SQJZF.After the administration for 50 days

levels of cholesterol（TC）

triglyceride（TG）

low density lipoprotein cholesterin（LDL-C）

high density lipoprotein cholesterin（HDL-C） and glucogn in muscle tissue were measured.Result:SQJZF showed good effects on the animal models.Compared with the model group

treatment with SQJZF at a dose of 6

1.5 g · kg-1 for 50 d decreased levels of TC

LDL-C and glucogn in muscle tissue（P<0.01）;levels of HDL-C was significantly elvated by treatment with SQJZF at a dose of 3 g · kg-1（P<0.01）.Conclusion:SQJZF may contribute to ameliorate the glucolipid metablization in diabetic skeletal muscle.

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Effect of Shengqing Jiangzhuo Fang on Glycolipid Metabolism in Monosodium -Glutamate Rats

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