Clinical Effect of Naomaitai Capsule on Vascular Dementia Patients

MA Yu1; PAN Xiu-qing1; REN Yue-qin2; LI Yan-lin3; ZHANG Jie-wen1

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Clinical Effect of Naomaitai Capsule on Vascular Dementia Patients

更新时间：2024-09-23

- Clinical Effect of Naomaitai Capsule on Vascular Dementia Patients
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 339-341(2013)
- 作者机构：
  
  1. 河南省人民医院
  2. 河南中医学院第二附属医院
  3. 郑州市第一人民医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R277.7
- Published：2013
- 稿件说明：
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[1]马瑜,潘秀清,任月琴,李彦玲,张杰文.脑脉泰胶囊治疗血管性痴呆41例[J].中国实验方剂学杂志,2013,19(09):339-341.

MA Yu1, PAN Xiu-qing1, REN Yue-qin2, et al. Clinical Effect of Naomaitai Capsule on Vascular Dementia Patients[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 339-341.
[1]马瑜,潘秀清,任月琴,李彦玲,张杰文.脑脉泰胶囊治疗血管性痴呆41例[J].中国实验方剂学杂志,2013,19(09):339-341. DOI：

MA Yu1, PAN Xiu-qing1, REN Yue-qin2, et al. Clinical Effect of Naomaitai Capsule on Vascular Dementia Patients[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 339-341. DOI：

摘要

目的:探讨脑脉泰胶囊对血管性痴呆轻、中度患者临床疗效及认知功能障碍的作用。方法:将82例血管性痴呆患者随机分为观察组和对照组各41例。观察组给予脑脉泰胶囊（2粒

3次/d

）口服

对照组给予脑复康（2片

3次/d）口服

疗程均为12周。评价两组的临床疗效及治疗前后简易精神状况检查量表（MMSE）评分和常见相关电位（P300）检测结果的变化情况。结果:治疗12周后

两组疗效优于对照组

差异有统计学意义（P<0.05）

两组治疗后MMSE评分、P300潜伏期及P300波幅较治疗前明显改善（P<0.05或P<0.01）

且观察组优于对照组（P<0.05）。结论:脑脉泰胶囊治疗轻、中度血管性痴呆有较好的疗效

不良反应少

且能促进认知功能障碍的恢复。

Abstract

Objective:To study the effect of Naomaitai capsule on cognitive dysfunction of vascular dementia patients.Method: Eighty four vascular dementia patients were randomly divided into therapeutic group and control group（n=41 each）.The therapeutic group was treated by Naomaitai capsule（2 capsules

tid） and the control group by Naofukang（2 tablets

tid）.The therapeutic course was 12 weeks.Before and after treatment

mimi-mental state examination（MMSE） grade and variation of frenquently appeared potential（P300） were evaluated.Clinical efficacy was evaluated for the two groups.Result: After the therapeutic course

the total efficacy of the observation group was better than that of the control group

the difference was statistically significant（p<0.05）.In two groups MMSE scores

P300 latency and P300 amplitude was significantly improved after treatment compared with those before treatment（P<0.05 or P<0.01）.The improvement in the treatment group was better than that in the controls.Conclusion: Naomaitai capsule for treating vascular dementia shows good efficacy and less adverse reactions.The capsule can promote cognitive recovery.

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Related Author

MA Yu

PAN Xiu-qing

REN Yue-qin

LI Yan-lin

ZHANG Jie-wen

LIU Wenfang

LIN Yang

LIU Xianfeng

Related Institution

Beijing Anzhen Hospital of Capital Medical University

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Hospital of Chengdu University of Traditional Chinese Medicine （TCM）

Chengdu University of TCM

Institute of Basic Research in Clinical Medicine，China Academy of Chinese Medical Sciences

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