Anti-inflammatory and Analgesic Effect of Sauropus rostratus

ZHEN Han-shen1; LIU Rong1; QIU Qin1; JIANG Jian-guo2; YANG Yong-yu2

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Anti-inflammatory and Analgesic Effect of Sauropus rostratus

更新时间：2024-09-23

- Anti-inflammatory and Analgesic Effect of Sauropus rostratus
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 270-273(2013)
- 作者机构：
  
  1. 广西中医药大学
  2. 广西北海市第二人民医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]甄汉深,刘蓉,丘琴,姜建国,杨永榆.龙利叶抗炎镇痛作用研究[J].中国实验方剂学杂志,2013,19(09):270-273.

ZHEN Han-shen1, LIU Rong1, QIU Qin1, et al. Anti-inflammatory and Analgesic Effect of Sauropus rostratus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 270-273.
[1]甄汉深,刘蓉,丘琴,姜建国,杨永榆.龙利叶抗炎镇痛作用研究[J].中国实验方剂学杂志,2013,19(09):270-273. DOI：

ZHEN Han-shen1, LIU Rong1, QIU Qin1, et al. Anti-inflammatory and Analgesic Effect of Sauropus rostratus[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 270-273. DOI：

摘要

目的:研究龙利叶水提液的抗炎和镇痛作用。方法:采用改良寇氏法对其急性毒性进行研究;采用二甲苯致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀、小鼠棉球肉芽肿增生模型

评价龙利叶水提液（含生药14

3.5 g.kg-1）的抗炎作用

采用扭体法和热板法评价其镇痛作用。结果:龙利叶水提液的LD50为68 g.kg-1

对二甲苯致小鼠耳廓肿胀、棉球致小鼠肉芽肿和角叉菜胶致大鼠足跖肿胀均有明显的抑制作用（P<0.05或P<0.01）

能显著减少醋酸致小鼠扭体反应的次数（P<0.05或P<0.01）

但不能提高小鼠的痛阈。结论:龙利叶水提液具有抗炎和镇痛作用

为龙利叶的开发和利用提供了科学依据。

Abstract

Objective:To study anti-inflammatory and analgesic effect of water extract of Sauropus rostratus.Method: The LD50level of the water extract was determined by modified Karber’s method.Dimethylbenzene-induced auricle edema in mice

carrageenan-induced hind paw edema in rats and cotton ball-induced granuloma in mice were respectively performed to investigate the anti-inflammatory effect of the extract（14

3.5 g · kg-1）.Mouse twisting numbers induced by acetic acid and mouse pain threshold after heat stimulation on hot-plate tests were respectively performed to investigate the analgesic effect of S.rostratus.Result:The LD50level of water extract of S.rostratus.was 68 g · kg-1

the auricle edema induced by dimethylbenzene in mice

catton ball-induced granuloma in mice and carrageenan-induced hind paw edema in rats were inhibited significantly by water extract of S.rostratus.（P<0.05 or P<0.01）

water extract of S.rostratus could remarkably reduce mouse twisting numbers（P<0.05 or P<0.01）

but could not improve pain threshold.Conclusion:The water extract of S.rostratus had anti-inflammatory effect and analgesic effect

the researches could provide a scientific basis for developing and utilizing of S.rostratus.

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