Effects of Guizhi Decoction and Its Disassembled Prescriptions on Dissolution of Paeoniflorin

WANG Rui1; ZHAN Xiao-ri2; LI Huan1

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Effects of Guizhi Decoction and Its Disassembled Prescriptions on Dissolution of Paeoniflorin

更新时间：2024-09-23

- Effects of Guizhi Decoction and Its Disassembled Prescriptions on Dissolution of Paeoniflorin
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 6-8(2013)
- 作者机构：
  
  1. 山西中医学院
  2. 杭州师范大学
  3. 中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC： R284
- Published：2013
- 稿件说明：
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[1]王瑞,展晓日,李欢.桂枝汤及其拆方对芍药苷溶出量的影响[J].中国实验方剂学杂志,2013,19(09):6-8.

WANG Rui1, ZHAN Xiao-ri2, LI Huan1. Effects of Guizhi Decoction and Its Disassembled Prescriptions on Dissolution of Paeoniflorin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 6-8.
[1]王瑞,展晓日,李欢.桂枝汤及其拆方对芍药苷溶出量的影响[J].中国实验方剂学杂志,2013,19(09):6-8. DOI：

WANG Rui1, ZHAN Xiao-ri2, LI Huan1. Effects of Guizhi Decoction and Its Disassembled Prescriptions on Dissolution of Paeoniflorin[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 6-8. DOI：

摘要

目的:研究桂枝汤拆方前后芍药苷的含量变化。方法:采用Diamonsil RP-C18色谱柱（4.6 mm×250 mm

5μm）

流动相乙腈-水

流速1.0 mL.min-1

检测波长230 nm。结果:桂枝汤拆方前后芍药苷含量由高到低的顺序为去大枣组>去生姜组>全方组>去桂枝组>去甘草组

去甘草组、去桂枝组与全方组比较均有显著性差异;去生姜组和去大枣组与全方组比较无显著性差异（P>0.05）。结论:甘草、桂枝均有助于白芍中芍药苷的溶出

生姜和大枣对白芍中芍药苷的溶出影响不大。

Abstract

Objective:To investigate effects of Guizhi decoction and its disassembled prescriptions on the content of paeoniflorin.Method:A gradient HPLC system was used in the quantitative analysis of paeoniflorin on Diamonsil RP-C18 column（4.6 mm×250 mm

5 μm） with acetonitrile and water as mobile phase

the flow rate was 1 mL·min-1and the detection wavelength was 230 nm.Result:The content of paeoniflorin had great changes comparing Guizhi decoction with its different disassembled prescriptions

the order of it was group 4>group 3>group 5>group 1>group 2;By comparing with group 5

group 2 and group 1 had significant differences（P<0.05）

but group 3 and group 4 had not.Conclusion:Radix Ei Rhizoma Glycyrrhizae and Ramulus Cinnamomi were helpful to the dissolution of paeoniflorin from Radix Paeoniae Alba

but Rhizoma Zingiberis Recens and Fructus Jujubae had few effects on it.

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Related Author

WANG Rui

ZHAN Xiao-ri

LI Huan

WANG Zhao-yu

BAI Xiu-yun

BAI Hai-yu

WANG Wei-ming

HUANG Ming-qing

Related Institution

Heilongjiang Academy of Traditional Chinese Medicine

The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital

Fuwai Central China Cardiovascular Hospital/Henan Provincial People's Hospital

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