Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria

CUI Hao-zhen1; LIU Li-ping2

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Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria

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- Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 9, Pages: 256-259(2013)
- 作者机构：
  
  1. 延边大学中医学院临床基础教研室
  2. 延边大学基础医学院生理学教研室
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2013
- 稿件说明：
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[1]崔昊震,刘丽萍.远志水提取物对家兔心肌收缩力及心房尿钠肽分泌的影响[J].中国实验方剂学杂志,2013,19(09):256-259.

CUI Hao-zhen1, LIU Li-ping2. Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 256-259.
[1]崔昊震,刘丽萍.远志水提取物对家兔心肌收缩力及心房尿钠肽分泌的影响[J].中国实验方剂学杂志,2013,19(09):256-259. DOI：

CUI Hao-zhen1, LIU Li-ping2. Aqueous Extract of Polygala tenuifolia Willd on Atrial Dynamics and ANP Secretion in Beating Rabbit Atria[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(9): 256-259. DOI：

摘要

目的:观察远志水提取物对家兔心肌收缩力及心房尿钠肽分泌的影响。方法:采用家兔离体搏动心房灌流模型

观察远志水提取物对家兔心肌收缩力及心房尿钠肽分泌的影响。环磷酸腺苷（cAMP）和心房尿钠肽（ANP）含量的测定均采用放射免疫法。结果:远志水提取物可使家兔的心房每回搏出量、搏动压和灌流液中cAMP流出量比给药前呈现剂量依赖性递增趋势（P<0.05）。同时

它还可以明显地抑制ANP的分泌（P<0.01）。在阻断β-肾上腺素受体（β-adrenorecptor

β-AR）及选择性阻断β1-AR时能显著抑制远志水提取物对心肌收缩力的增强作用（P<0.05）;而选择性阻断β2-AR时却无任何影响。此外

阻断L-型Ca2+通道及选择性抑制蛋白激酶A（PKA）的活性能明显抑制远志水提物对心肌收缩力的增强作用（P<0.05）。结论:远志水提取物主要通过影响β1-AR-cAMP-Ca2+信号传导途径增强心肌收缩力

并对ANP分泌具有抑制作用。

Abstract

Objective:To investigate the effect of aqueous extract of Polygala tenuifolia（APT） on myocardial contractility and atrial natriuretic peptide（ANP） secretion in beating rabbit atria.Method: The APT-induced changes in atrial dynamics

cAMP efflux and ANP secretion were determined in perfused beating rabbit atria.The changes of cAMP and ANP were measured by radioimmunoassay.Result: APT increased atrial stroke volume

pulse pressure and cAMP efflux in a concentration-dependent manner with inhibition of ANP secretion in beating rabbit atria.The APT-induced positive inotropic effect was significantly blocked by pretreatment with blockade of β and β1-adrenoceptors（AR）（P<0.05） but not β2-AR.Furthermore

the APT-induced changes in myocardial contractility were attenuated by inhibition of L-type Ca2+channel and protein kinase A（PKA） activation with no changes in cAMP efflux.Conclusion: APT could increase atrial dynamics via β1-AR-cAMP-Ca2+signaling and decreases ANP secretion in beating rabbit atria.

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