Abstract:Aim：Perorm serum pharmacochemistry study on extract in Shuxiong Tablets. Methods：HPLC research on the serum fingerprints chromatograms of Shuxiong tablet extract based on blood serum chemical pharmacy: After SD rats are administrated by gavages

samples are taken respectively after certain periods and measures are made on serum chromatograms of both mixed extracts and each single extract

then analysis is made. including 16 components can be detected in the fingerprint serum

including 5 of the serum itself

and the other 11 may come from the original compound and their metabolites. Conclusion：the 6 major components of Shuxiong tablet (ligustazine、hydroxysafflor yellow A、ferulic acid、notoginsenoside R1、ginsenoside Rg1、ginsenoside Rb1) which are in the blood or transitional elements in the blood. The serum chromatograms of Shuxiong tablet are established on the basis of serum HPLC fingerprint chromatograms and compound HPLC fingerprint chromatograms. Results：HPLC research on fingerprint chromatograms is simple and reproducible

and the fingerprint chromatograms can reflect multi-ingredients in the Shuxiong tablet

therefore

this study provides a reliable method for the effective quality control of Shuxiong tablet

and prepares for in-depth study on the tablet.