Objective: To investigate the clinical efficacy of Tanreqing injection and Compound Danshen injection combined with antibiotic for treatment of drug-resistant bacterial infections of the lower respiratory tract in elderly. Method: Six hundred and forty-seven patients formed a natural team cases according to whether the use of traditional Chinese medicine(Tanreqing injection and Compound Danshen injection).After drug-resistant screening

54 cases of drug-resistant bacteria in the observation group (total 284 cases) and 72 cases in the control group(total 363 cases).Both groups were treated with antibiotics empirically

and make adjustments based on susceptibility results.The observation group was treated with Tanreqing injection and Compound Salvia injection(20 mL in 250 mL normal saline

iv dripping) for 14 days.Clinical symptoms

signs

and sputum bacterial clearance rate were investigated. Result: There were 126 cases of drug-resistant patients

accounting for 19.47%(126/647).Resistant pathogens were gram-negative bacilli.The symptoms of physical disease integral in the observation group was lower than that in the control group after 4 d and 14 d of treatment(P<0.05 and P<0.01).The efficacy of the observation group was better than that of the control group(P<0.05).Bacteriological efficacy of the observation group was better than that of the control group(P<0.01). Conclusion: Tanreqing injection and Danshen injection combined with antibiotics can inhibit and treat drug-resistant bacterial infections of the lower respiratory tract

and reduce the clinical symptoms and signs

improve the clinical efficacy.