Objective: To examine the effect of treatment of continuous positive airway pressure (CPAP) combined with traditional Chinese medicine on inflammation factors in exhaled breath condensate (EBC) of patients with obstructives sleep apnea-hypopnea syndrome (OSAHS). Method: Sixty OSAHS patients were divided into two groups: control group (CPAP group)

observe group (CPAP with traditional Chinese medicine group)

each 30 cases

and another 10 cases of health people as normal group.Control group was received CPAP and observation group received CPAP with traditional Chinese medicine.Traditional Chinese medicine were Xianzhuli oral liquid(20 mL

bid)

Qingyandi pill(4-6 pills tid) and Bingyong Tongmai lozenge (l piece under tongue

tid).We collected the patient's EBC before treatment and 3 months after treatment and analized the inflammation factors of interleukin-6(IL-6)

interleukin-8(IL-8)

tumor necrosis factor (TNF-α) in EBC. Result: The concentration of IL-6 and TNF-α in control group and observation group were significant higher than those in normal group (P<0.01).After treatment

apnea-hypopnea index (AHI) of control group and observation group was decreased significantly than those before treatment (P<0.01).Night minimum oxygen saturation of control group and observation group were increased significantly than those before treatment (P<0.01).The concentration of IL-6 and TNF-α in control group and observation group were significant lower than those before treatment (P<0.01).The improving of indexes in observation group was better than those in control group(P<0.01).The effective rate in observation group (90.0%) was better than that in control group(56.66%) (P<0.01). Conclusion: Treatment of CPAP combined with traditional Chinese medicine can decrease the inflammatory reaction in patients of OSAHS to improve the effect.