Objective:To study the effect of traditional Chineses herbs with reinforcing qi

warming yang

activating blood and promoting diuresis in improving hemodynamic abnormity in rabbits with heart failure

then to decide their best compatibility proportion. Method: Seventy-two rabbits were randomly diveded and equally into 9 Chinese herb groups

digoxin group

model group and sham-operated group. Rabbit model of pressure overloaded heart failure was induced by costricting abdominal aorta. According to L9 (34) orthogonal design

all groups were given corresponding traditional Chinese compounds. Digoxin group was given digoxin. model group was given saline. Hemodynamic parameters of left ventricular were detected through carotid artery cannula ten days later. Result: Carotid systolic blood pressure(SBP)

carotid diastolic blood pressure(DBP)and left ventricular systolic pressure(LVSP)in Chinese herb groups and digoxin group increased significantly

compared to model group and sham-operated group (P＜0.05 or P＜0.01).±dp/dtmax

+dp/dtmax in Chinese herb groups(1-4

7-9) and digoxin group increased significantly

compared to model group (P＜0.05 or P＜0.01). But±dp/dtmax and+dp/dtmax in Chinese herb groups(5

6) and sham-operated group compared with model group

there was no significant difference. Left ventricular end diastolic pressure(LVEDP) and-dp/dtmax of every group were insignificantly differenet. Conclusion: Herbs with reinforcing qi

warming yang

activating blood and promoting diuresis can improve hemodynamic abnormity and systolic function of rabbit model with heart failure

delay the development of heart failure. The best compatibility proportion of four kinds of herbs might be 4∶2∶1∶4

dosage of reinforcing qi is 8.67 g·kg-1

dosage of warming yang is 4.33 g·kg-1

dosage of activating blood is 2.17 g·kg-1

dosage of promoting diuresis is 8.67 g·kg-1.