Objective: To study the contribution of high-sensitivity C reactive protein (hs-CRP) and homocysteine (Hcy) on coronary lesions and investigate the association of that with traditional cardiovascular risk factors in postmenopausal women. Method: This study involved 150 consecutive postmenopausal women (CHD female group) with coronary heart disease (CHD)

150 consecutive men with CHD (male group) and 146 postmenopausal women with non-CHD (non-CHD female group).All patients underwent coronary angiography.The levels of hs-CRP and Hcy were detected in three groups.The association of hs-CRP

Hcy with coronary lesions and traditional cardiovascular risk factors was analyzed. Result: There were significant difference traditional cardiovascular risk factors including hypertension

type 2 diabetes in CHD female group than male group

the levels of hs-CRP and Hcy higher in CHD female group

but smoking and glomerular filtration rate(GFR) lower in CHD female group.In postmenopausal women

increased number of compromised arteries and total Gensini scores for the lesions were associated with increased levels of hs-CRP and Hcy.Correlation analysis showed a significant correlation among hs-CRP and Hcy(r=0.472

P<0.001); Hcy and body mass index(BMI)

systolic blood pressure(SBP)

diastdic blood pressure(DBP); hs-CRP and BMI

SBP in postmenopausal women. Conclusion: The levels of hs-CRP and Hcy significant increased in postmenopausal women

and associated with each other.There was significant correlation among two newly emerged cardiovascular risk factors and obesity

hypertension.