Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays
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Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 5, Pages: 1-3(2013)
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Published:2013
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GE Ke-ya, DU Mao-bo, LIU Shu-zhi, et al. Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 1-3.
DOI:
GE Ke-ya, DU Mao-bo, LIU Shu-zhi, et al. Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 1-3.DOI:
Investigation of Transdermal Permeation Effect of Wantong Jingu Sprays
摘要
目的: 考察万通筋骨喷雾剂的经皮渗透效果。 方法: 以绿原酸为指标
采用垂直式改良Franz扩散池装置进行试验
HPLC测定含量。 结果: 万通筋骨喷雾剂样品的透皮速率27.919 μg·cm-2·h-1
6 h内平均累积透过率13.53%;绿原酸喷雾剂的透皮速率6.636 μg·cm-2·h-1
6 h内平均累积透过率3.78%。 结论: 万通筋骨喷雾剂的体外透皮行为符合零级方程
其经皮渗透效果优于绿原酸喷雾剂。
Abstract
Objective:To investigate transdermal permeation effect of Wantong Jingu sprays. Method: Modified Franz diffusion cell was applied to investigate in vitro transdermal absorption behavior of Wantong Jingu sprays
with the content of chlorogenic acid as index
which was determined by HPLC. Result: In six hours
accumulated transdermal rate of Wantong Jingu sprays and chlorogenic acid sprays were 13.53%
3.78%
respectively; Transdermal rate were 27.919
6.636 μg·cm-2·h-1
respectively. Conclusion: In vitro transdermal absorption behavior of Wantong Jingu sprays was in accordence with zero-level equation
its transdermal absorption effect was better than chlorogenic acid sprays.