Optimization of Prescription Technology for Nasturtium Total Flavonoids Dispersible Tablets
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Optimization of Prescription Technology for Nasturtium Total Flavonoids Dispersible Tablets
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 6, Pages: 8-11(2013)
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Published:2013
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SU Zhan-hui, WANG Shu-jun, ZHANG Zi-ming, et al. Optimization of Prescription Technology for Nasturtium Total Flavonoids Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 8-11.
DOI:
SU Zhan-hui, WANG Shu-jun, ZHANG Zi-ming, et al. Optimization of Prescription Technology for Nasturtium Total Flavonoids Dispersible Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 8-11.DOI:
Optimization of Prescription Technology for Nasturtium Total Flavonoids Dispersible Tablets
Objective: To optimize prescription technology of nasturtium total flavonoids dispersible tablets. Method: Single factor test was used to investigate lubricants
fillers
adhesion agents and disintegration agents;With disintegration time as index
orthogonal test was used to optimize prescription technology of nasturtium total flavonoids dispersible tablets with quality of MC
PVPPXL-10
PEG 6000 and PVPPXL as factor. Result: Optimum prescription process was as following:with MC as fillers
PEG 6000 as lubricants
95% ethanol as adhesion agents
PVPPXL-10 and PVPPXL as disintegration agents;Dry cream powder of total flavonoids from Trollius chinensis 200 g(50%)
MC 148.48 g(37.12%)
PVPPXL-10 34.09 g(8.52%)
PVPPXL 11.36 g(2.84%)
PEG 6000 6.06 G(1.52%)
made of 1 000 tablets.Disintegration time of these prepared tablets were less than 3 min
tablet weight 0.4 g
tablets disintegrate within 3 min were through the 2nd sieve
uniformity qualified compliance. Conclusion: This prescription process was stable and feasible with good traceability
it could provide experimental basis for quality standard of nasturtium total flavonoids dispersible tablets.
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Related Institution
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