Objective:To observe the clinical efficacy and part of the mechanism of Jiawei Zhaqu yin in treating the non-alcoholic fatty liver. Method: Fourty-six patients with non-alcoholic fatty liver disease were randomly divided into treatment group and control group.Treatment group of 24 patients was treated with Jiawei Zhaqu yin and control group of 22 cases with Dangfei Liganning pian.12 weeks after treatment

the 1evel of liver B-mode ultrasound

serum alanine transaminase (ALT)

aspartate amino transferase (AST)

transforming growth factor-beta1(TGF-β1)

and superoxide dismutase (SOD)of the patients with non-alcoholic fatty liver disease were observed. Result: After treatment

the serum ALT and AST of the two groups were significantly decreased(P<0.05).Compared with the control group

the serum ALT and AST of the treatment group patients had no significant difference.After treatment

histological liver lesions of two groups of patients had improved to a certain extent

prompted by Color B-mode ultrasonography.After treatment

the serum TGF-β1 of the patients in the treatment group decreased significantly(P<0.05)

while serum SOD increased(P<0.05). Conclusion: Jiawei Zhaqu yin plays a significant hepatoprotective effect on patients with non-alcoholic fatty liver disease

while it also can improve liver histological lesions.This may be related to reducing serum TGF-β1

elevated serum SOD of non-alcoholic fatty liver disease patients

exerting anti-inflammatory

antioxidant effect.