Pathological Influence of Jintiange Capsule on Osteoarthritis in Rats
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Pathological Influence of Jintiange Capsule on Osteoarthritis in Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 6, Pages: 287-290(2013)
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Published:2013
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HOU Xiao-li, ZHAO Lin-tao, SONG Yan-ping. Pathological Influence of Jintiange Capsule on Osteoarthritis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 287-290.
DOI:
HOU Xiao-li, ZHAO Lin-tao, SONG Yan-ping. Pathological Influence of Jintiange Capsule on Osteoarthritis in Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 287-290.DOI:
Pathological Influence of Jintiange Capsule on Osteoarthritis in Rats
Objective: To observe influence of Jintiange capsules (JC) on articular cartilage lesions and osteoarthritis induced by papain in rats. Method: Adult male SD rats were divided into sham operated group
model group
Xianling Gubao (XG) group(0.80 g·kg-1)
JC high
medium and low (0.96
0.48
0.24 g·kg-1) dose groups.The bilateral knee joint cavities were injected with papain 20 μL to induce osteoarthritis.Three weeks after the establishment of the models
different drugs were lavaged for 4 weeks.Then the rats were sacrificed and the knee joint cartilage was collected.Pathological section and microscopic observation were carried out for evaluating joint cartilage lesions. Result: Articular cartilage in model group showed thin rough surface
fiber fracture
tide line disappear
cell arrangement disorder
cell clusters
part of the joint synovial hyperplasia and finger-shaped bulge towards the joint cavity.JC of 3 doses showed different degree of alleviation for the pathological changes. Conclusion: JC can repair the damage of cartilage surface of articular cartilage with protective role.