Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules

LI Ji; LI Ling-jun; LOU Hua-wei

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Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules

更新时间：2024-01-04

- Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 6, Pages: 167-170(2013)
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- Published：2013
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LI Ji, LI Ling-jun, LOU Hua-wei. Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 167-170.
DOI：

LI Ji, LI Ling-jun, LOU Hua-wei. Intestinal Absorption Kinetics Study of Rhynchophylline and Isorhynchophylline of Tiangou Jiangya Capsules[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 167-170. DOI：

摘要

目的: 研究天钩降压胶囊中钩藤碱、异钩藤碱在大鼠肠道的吸收动力学。方法: 采用大鼠在体肠灌流试验

利用HPLC测定钩藤碱、异钩藤碱的含量KROMASIL C18色谱柱(4.6 mm×200 mm

5 μm)

流动相乙腈-水(含0.01 mol·L-1三乙胺

冰醋酸调pH 7.5)(45:55)

流速1 mL·min-1

检测波长254 nm

柱温30 ℃

进样量20 μL

用紫外-可见分光光度法在560 nm测定酚红的含量。结果: 钩藤碱吸收动力学方程为Y=-0.331 7X-0.771 8(r=0.998 5)

Ka=0.331 7(h-1)

t1/2=2.09(h);异钩藤碱吸收动力学方程为Y=-0.687 0X-0.150 4(r=0.985 2)

Ka=0.687 0(h-1)

t1/2=1.01(h)。结论: 天钩降压胶囊中钩藤碱、异钩藤碱在大鼠在体小肠的吸收呈一级动力学过程。

Abstract

Objective: To study in vivo intestinal absorption kinetics of rhynchophylline and isorhynchophylline of Tiangou Jiangya capsules. Method: HPLC method was used to determine the content of rhynchophylline

isorhynchophylline and Ultra-violet (UV) spectrophotometry was used to determine the content of phenol red in the rat in vivo intestinal perfusion tests. Result: The regression of rhynchophylline is Y=-0.331 7X-0.771 8(r=0.998 5)

Ka=0.331 7(h-1)

t1/2=2.09(h). The regression of isorhynchophylline is Y=-0.687 0X-0.150 4(r=0.985 2)

Ka=0.687 0(h-1)

t1/2=1.01(h). Conclusion: The absorption of rhynchophylline and isorhynchophylline of Tiangou Jiangya capsules in rat's intestine comply with the first-order kinetics process.

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