Objective:To investigate relationship between deposition amount and time of breviscapine common gel and solid lipid nanoparticle(SLN) gel in mice abdominal skin

and their topical pharmacokinetic of transdermal drug delivery.To investigate mechanism of SLN gel in enhancing breviscapine to penetrate into skin. Method: To set up an assaying methodology of breviscapine deposition amount in skin and compare accumulation deposition amount of breviscapine in skin between common gel and SLN gel

pharmacokinetics parameters were fitted by DAS software

in order to discuss topical pharmacokinetic of these two gels. Result: Within 24 h

per unit area deposition amount of breviscapine in skin of common gel were 1.73 times more than SLN gel;Dermatopharmacokinetic process of SLN gel and common gel were fitted with tow-compartment model and one-compartment model

respectively

AUC0-24 were 17.804

24.675 mg·L-1·h and T1/2 were 10.855

15.534 h

respectively. Conclusion: Transdermal degree and speed of SLN gel were greater and faster than common gel

which showed that SLN gel had function to enhance drug to penetrate into skin.