Objective: To study the acute and chronic toxicity of Shenyuan tablet. Method: Shenyuan tablet was intragastrically administered a time to mice in range of one day. Determine the median lethal dose (LD50).Animal appearance

behavior

mental status

respiratory changes and the number of animals poisoned and die in each group were noted daily for 14 consecutive days. The amount of weight and feed of survived mice were recorded every day. The chronic toxicity was performed in rats

the treatment groups (minimum

middle

maximum dose of Shenyuan tablet.) and control group were made. After continuously feeding rats orally for 6 months

we observed the rats behavior

weight gain

food consumption

blood test

biochemistry test

urine test

electrocardiogram

systematic autopsy and pharmacology test. The above physiological signs were inspected again 1 month after cease of feeding. Result: The oral acute toxicity study of Shenyuan tablet. In mice revealed that the maximum dose is 97.46 g·kg-1

which was 568 times the maximum recommended human dose in the clinic practice. No significant differences were observed in rat's behaviors

food intake

electrocardiogram and relative examination indexes among the 3 different dosage groups of Shenyuan tablet. Which compared with normal control group. There was no abnormal condition for the results of blood test

biochemistry test

urine test and pharmacology test for the rats. The liver and kidney weight and liver (kidney)/rat weight have significant increase in the group of Shenyuan tablet maximum dose. And the feces are soft. Conclusion: The minimum dosage of Shenyuan tablet. is relatively safe. The shenyuan table

especially at high doses

may lead to potential liver and kidney toxic risk

so it should be paid attention in clinical studies.