Objective:To optimize Aloe moisturizing active ingredients and to evaluate their skin adaptability. Method: Moisturizing active ingredients of Aloe were optimized with the skin hydrated state and transepidermal water loss test method. Skin adaptability of the moisturizing active ingredients was evaluated by erythrocyte hemolysis method

franz diffusion cell in vitro transdermal absorption method and the human skin patch test method

respectively from the biocompatibility

skin permeability and skin safety three aspects. Result: Aloe polysaccharide components showed excellent moisturizing efficacy

significantly improving skin hydration status (P<0.05)

at the same time

reducing the skin water loss (P<0.05). Different concentrations of aloe polysaccharide solution (2

20 g·L-1) to the erythrocyte hemolysis rate was lower than 0.3%

far below the blood compatibility of the conventional value

with human body compatibility degree was high. Polysaccharide mass concentration was 5%

the skin penetration rate was 0.251 mg·h·cm-2

and the quantity of the transdermal absorption reached (4.152±0.046) mg·cm-2 in 24 hours; in the human skin patch test all evaluation showed zero level reaction

so it should be highly safe for human application. Conclusion: Aloe active polysaccharide has significant moisturizing efficacy and good skin adaptability. It can be widely used in dermatology

as a excellent moisturizing cosmetics additive.