Objective: To study the characteristics of blood nourishing and blood circulation activating efficacy preference of the Angelicae Sinensis Radix herb pairs. Method: ICR mice

half male and half female

were randomly divided into control group

model group

Angelicae Sinensis Radix - Rehmanniae Radix Preparata (Danggui-Shudihuang)

Angelicae Sinensis Radix-Astragali Radix (Danggui-Huangqi)

Angelicae Sinensis Radix-Paeoniae Radix Alba (Danggui-Baishao)

Angelicae Sinensis Radix-Paeoniae Rubra Radix (Danggui-Chishao)

Angelicae Sinensis Radix-Chuanxiong Rhizoma(Danggui-Chuangxiong) and Angelicae Sinensis Radix\|Persicae Semen (Danggui-Taoren) groups (10.4 g·kg-1). Control and model groups were ig given the same volume physiological saline for 8 days. Acetylphenyhydrazine and cyclophosphamide were used to copy the blood-deficiency model mice by ip cyclophosphamide (200 mg·kg-1) at the first day and sc acetylphenyhydrazine (100 mg·kg-1) at the sixth day. Periphera hemogram

organ index and BRC ATPase activity were detected at the 8th day to compare the blood nourishing efficacy. SD rats

half male and half female

the same group as above (7.2 g·kg-1)

control and model groups were ig given the same volume physiological saline for 7 days. Epinephrine hydrochlaride and ice-water stimulation were used to copy acute blood stasis model rats by sc acetylphenyhydrazine (0.8 mg·kg-1) at the 6th day(interval of 4 h

2 times) and ice-water stimulation for 4 min. Aemorheology

blood clotting tetrachoric index were detected at the 7th day to compare the blood circulation activating efficacy. Result: Compared with model group

Danggui-Baishao

Danggui-Huangqi and Danggui-Shudihuang could increase HGB(P<0.01)

HCT (P<0.01 or P<0.05) and reduced SI (P<0.01) and had better blood nourishing effect. Danggui-Shudi

Danggui-Chuanxiong

Danggui-Chishao and Danggui-Taoren could reduce whole blood low reduction viscocity

bood sedimentation equation K

and AI (P<0.01 or P<0.05) and lengthen APTT (P<0.01) and had better blood activating effect. Conclusion: Danggui-Baishao and Danggui-Huangqi herb pairs have better blood nutriting efficacy. Danggui-Chuanxiong

Danggui-Chishao and Danggui-Taoren herb pairs have better blood circulation activating efficacy. Danggui-Shudihuang herb pairs have well nutriting and circulation activating efficacy at the same time.