Study on the Law of Compatibility in Yougui Pill based on Decision Rules Model and Uniform Design

WANG Xiu-feng; ZHANG Lei; TANG Xiao-ya; DENG Shu-yong; LUO Lai-cheng

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Study on the Law of Compatibility in Yougui Pill based on Decision Rules Model and Uniform Design

更新时间：2024-09-23

- Study on the Law of Compatibility in Yougui Pill based on Decision Rules Model and Uniform Design
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 3, Pages: 321-324(2013)
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- Published：2013
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WANG Xiu-feng, ZHANG Lei, TANG Xiao-ya, et al. Study on the Law of Compatibility in Yougui Pill based on Decision Rules Model and Uniform Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 321-324.
DOI：

WANG Xiu-feng, ZHANG Lei, TANG Xiao-ya, et al. Study on the Law of Compatibility in Yougui Pill based on Decision Rules Model and Uniform Design[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 321-324. DOI：

摘要

目的: 利用基于粗糙集理论的决策规则模型评价右归丸的疗效

探究其中补阴药、补阳药和边缘药的相互作用及地位

进而改进右归丸的配伍。方法: 把大鼠分为正常组、肾阳虚模型组、右归丸原方组以及右归丸均匀设计的药方组5组

共8组。分别检测其四碘甲腺原氨酸(T4)

皮质醇(CORT)和睾酮(T)。建立基于粗糙集的决策规则模型

通过决策规则分析补阴药、补阳药和边缘药3者之间的相互作用。结果: 右归丸中补阴药和补阳药之间具有协同作用;同时右归丸的边缘药对补阴药有促进作用;当右归丸的补阳药药量较小时

边缘药对其有促进作用

当补阳药药量较大时边缘药与补阳药之间有拮抗作用。结论: 右归丸的配伍应注重阴阳并补、阴阳互济

补阴补阳同样重要;同时要根据右归丸中补阳药的药量来确定合适的边缘药药量

以提高整个复方的药效。

Abstract

Objective:To evaluate the efficacy of Yougui pill with decision rules model based on rough set

to explore the interactions and position of the Yin-tonifying herbs

the Yang-tonifying herbs and the edge herbs

and then to improve the compatibility of Yougui pill. Method: The rats were divided into 8 groups

ie normal group

model group of kidney-yang deficiency

the original prescription group and five prescription groups by uniform design of Yougui pill. T4

CORT and T values were detected respectively. The decision rules model based on rough set was set up. The interactions among the Yin-tonifying herbs

the Yang-tonifying herbs and the edge herbs were analyzed according to the decision rules. Result: There were synergies between the Yin-tonifying herbs and the Yang-tonifying herbs in Yougui pill. There were synergies between the edge herbs and the Yin-tonifying herbs. There were synergies between the edge herbs and the Yang-tonifying herbs when the amount of the Yang-tonifying herbs were small

while the edge herbs antagonistic with the Yang-tonifying herbs when the amount of the Yang-tonifying herbs were large in Yougui pill. Conclusion: The compatibility of Yougui pill should focus on benefiting both yin and yang

as well as mutual rooting of Yin-yang. The amount of the edge herbs was determined according to the amount of Yang-tonifying herbs in order to improve the efficacy of Yougui pill.

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Related Author

WANG Xiu-feng

ZHANG Lei

TANG Xiao-ya

DENG Shu-yong

LUO Lai-cheng

LU Xianying

GAO Jing

BAI Dingxi

Related Institution

Guangdong Pharmaceutical University

School of Nursing， Chengdu University of Traditional Chinese Medicine

Institute of Chinese Materia Medica，China Academy of Chinese Medical Sciences

Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine

The MOE Key Laboratory for Standardization of Chinese Medicines and the Shanghai Key Laboratory for Compound Chinese Medicines， Institute of Chinese Materia Medica， Shanghai University of Traditional Chinese Medicine

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