Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC
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Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 6, Pages: 145-147(2013)
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Published:2013
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WANG Su-hui, YAN Hui, SUN Xiao-di, et al. Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 145-147.
DOI:
WANG Su-hui, YAN Hui, SUN Xiao-di, et al. Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 145-147.DOI:
Simultaneous Determination of Ephedrina Hydrochloridum and Pseudoephedrine Hydrochloride in Xiaoerganmaodan Patch by HPLC
Objective: This study is aimed to develop and validate a HPLC method for quantitative analysis of ephedrina hydrochloridum and pseudoephedrine hydrochloride in Xiaoerganmaodan Patch. Method: Phedrina hydrochloridum and pseudoephedrine hydrochloride were analyzed quantitatively by HPLC method. Result: A good linearity was obtained over the concentration range of 0.12-0.60 μg for ephedrina hydrochloridum (r=0.999 9)
and 0.148-0.740 μg for pseudoephedrine hydrochloride (r=0.999 8).The average recovery of ephedrina hydrochloridum was 100.8%(RSD 1.8%)
and the average recovery of pseudoephedrine hydrochloride was 99.12%(RSD 1.4%)
respectively. Conclusion: The results of the study showed that the HPLC method was simple
sensitive and selective.It is suitable for the quality control of this preparation.
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