Optimization of Preparation Technology for Heme Ferrous Tablets

PENG Hui; ZHANG Ming-hui; YIN Guang-ling

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Optimization of Preparation Technology for Heme Ferrous Tablets

更新时间：2024-01-04

- Optimization of Preparation Technology for Heme Ferrous Tablets
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 6, Pages: 63-65(2013)
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- Published：2013
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PENG Hui, ZHANG Ming-hui, YIN Guang-ling. Optimization of Preparation Technology for Heme Ferrous Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 63-65.
DOI：

PENG Hui, ZHANG Ming-hui, YIN Guang-ling. Optimization of Preparation Technology for Heme Ferrous Tablets[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(6): 63-65. DOI：

摘要

目的: 优化血红素亚铁片的制备工艺条件。方法: 以崩解时限和脆碎度为指标

采用单因素试验考察稀释剂、崩解剂;选取糊精蔗糖质量比、羧甲基淀粉钠及聚乙烯吡咯烷酮(PVP)质量分数为考察因素

通过单因素试验和正交试验优选血红素亚铁片的制备工艺。结果: 最佳制备工艺条件为糊精-蔗糖0.6:1

PVP质量分数15%

羧甲基淀粉钠质量分数3%。结论: 优选的工艺合理可行

制备的血红素亚铁片具有良好的脆碎度和崩解时限。

Abstract

Objective: To optimize preparation technology conditions of heme ferrous tablets. Method: With disintegration time and friability as indexes

diluents and disintegrating agents were investigated by single factor test;Orthogonal test and single factor test were used to optimize preparation technology of heme ferrous tablets with ratio of dextrin and sucrose

the mass fraction of sodium carboxymethyl starch and PVP as factors. Result: Optimum preparation technology was as following:dextrin-sucrose 0.6:1

the concentration of PVP 15%

sodium carboxymethyl starch 5%. Conclusion: This optimized technology was reasonable and feasible

these prepared tablets had good friability and disintegration time.

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