Objective:To study ampelopsin on apoptosis in human gastric cancer cells (SGC-7901). Method: Cell proliferation inhibition rate was measured by MTT

The situation in different apoptosis phase was evaluated by flow cytometry (Annexin-V/PI double staining). Result: Ampelopsin could significantly promote early apoptosis in SGC-7901 after 48 h. Ampelopsin of 50 and 75 mg·L-1 induced apoptosis of (29.03±6.21)%

and (43.43±1.00)% with a dose-dependent relationship

significantly higher than that in the control group (11.83±4.67)% (P<0.05

P<0.01

P<0.01). Cells in G1 phase was (52.07±4.41)%

(57.07±2.70)%

(58.43±2.66)%

significantly higher than (42.00±3.04)% in control group (P<0.05

P<0.01

P<0.01). Conclusion: Ampelopsin could induce the SGC-7901cell apoptosis and block the cells in G1 phase.