Objective: To study the protective effects of Yiganqing on acute hepatic injury in mice. Method: The healthy mice were divided into six groups at random

ten in each group: normal control group

model group

Bifendate group

Yiganqing high

middle and low dose group(30

15

7.5 g·kg-1 of crude drug

respectively).The mice in treatment groups were intragastric administration respectively

measwhile

the mice in normal control and model groups were treated with the same dose of distilled water

once a day for ten days.The models of liver injury induced by Carbon tetrachloride and D-galactosamine in mice were used.The activities of serum alanine aminotransferase(ALT) and aspartate aminotransferase (AST) were determined

and the pathological change of liver tissue was observed. Result: In the mouse models induced by Carbon tetrachloride

the level of ALT in serum of rats in the middle dose group and the high dose group of Yiganqing was reduced significantly (P<0.05 or P<0.01).The level of AST in serum of rats in the high dose group of Yiganqing was reduced significantly (P<0.05).And the liver pathological injury was alleviated obviously.In the mouse models induced by D-galactosamine

the levels of ALT and AST in serum(P<0.05) could be reduced significantly in the high dose group of Yiganqing and protect the liver from pathological injury. Conclusion: Yiganqing has protective effects on acute hepatic injury in mice.