Objective: To study the effect of Yinhua Paidu capsule(Ⅰ) in anti-acne

anti-inflammatory and analgesia

and to provide more data for further research of Ⅰ. Method: Acne model induced by coal tar in rabbits were established

rabbits were randomly divided into normal group

model group

Jiedu Cuochuang Wan group(1.68 g·kg-1)

Ⅰ high

middle and low dose groups(3.26

1.63

0.82 g·kg-1)

oral administration for two weeks

changes on modeling parts of the skin were observed and acne model was examined by histopathologic examination. Paw edema model induced by egg white in rats were established

rats were randomly divided into model group

Jiedu Cuochuang Wan group(3.24 g·kg-1)

Ⅰ high

middle and low dose groups(6.30

3.15

1.58 g·kg-1)

oral administration for 5 d

paw volume change were measured. Ear edema model caused by xylene and pain model induced by glacial acetic acid in mice were established

mice were randomly divided into model group

Jiedu Cuochuang Wan group(4.68 g·kg-1)

Ⅰ high

middle and low dose groups(9.10

4.55

2.28 g·kg-1). Oral administration for 5 d

auricle inflammatory swelling and writhing response were observed. Result: The experiments showed that the there dose groups of Ⅰ could significantly reduce the acne formation intension and reaction intension(P<0.01); also could significantly reduce the pinna tumidness of the mice and the vola pedis tumidness of the rats; the high and middle dose groups of Ⅰ also could decread the writhing response remarkedly

but the low-dose group hasd no effect on writhing response. Conclusion: Ⅰ have the effect of anti acne

anti-inflammatory and analgesia. It may have a good market prospect.