Objective:To explore the prevention effect of Xuebijing injection on radiation-induced lung injury in patients with non-small cell lung cancer (NSCLC). Method: Eighty three cases of NSCLC patients underwent radiotherapy and confirmed by pathological examinations were randomly divided into two groups. The treatment group (n=42) received Xuebijing injection from the first day of radiotherapy

the control group (n=41) received radiotherapy alone. The levels of tumor necrosis factor-α (TNF-α)

coagulation function

KPS scoring

and incidence of radiation-induced lung injury within 6-month-follow up were observed. Result: The levels of TNF-α in the two groups at the second week and the end of radiotherapy increased obviously

while the increasing degree in the treatment group was obviously smaller than that in the control group. The coagulation function in the two groups had different degree of deterioration

while the deterioration degree in the treatment group was smaller than that in the control group. The KPS scoring in the treatment group at the second week and the end of radiotherapy decreased slightly

and obviously increased 6 months after radiotherapy

and was also higher than that in the control group at the end of radiotherapy and 6 months after the end of radiotherapy. The incidences of early and advanced radiation-induced lung injury in the treatment group were obviously lower than that in the control group. Conclusion: Xuebijing injection has the effect on anti-endotoxin

reducing inflammation factors releasing

adjusting anticoagulation and coagulation function

and increasing the KPS scoring

so as to effectively prevent radiation-induced lung injury and improve the life quality of the patients.