Optimization of Preparation Technology of Changyan Granule

LIANG Hai-ning; LIU Xiao-shuan; SHEN Tao; BI Ying-yan

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Optimization of Preparation Technology of Changyan Granule

更新时间：2024-01-04

- Optimization of Preparation Technology of Changyan Granule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 1, Pages: 53-55(2013)
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- Published：2013
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LIANG Hai-ning, LIU Xiao-shuan, SHEN Tao, et al. Optimization of Preparation Technology of Changyan Granule[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 53-55.
DOI：

LIANG Hai-ning, LIU Xiao-shuan, SHEN Tao, et al. Optimization of Preparation Technology of Changyan Granule[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 53-55. DOI：

摘要

目的: 优选肠炎颗粒的制备工艺

并考察其醇沉工艺和成型工艺。方法: 以干膏质量和盐酸小檗碱质量分数的综合评分为指标

选取提取时间、提取次数及加水量为考察因素

采用正交试验优选肠炎颗粒的提取工艺;单因素试验考察其醇沉工艺;以颗粒成型性、流动性、吸湿性和制粒情况为指标

筛选辅料的种类及配比

确定成型工艺。结果: 最佳提取工艺为加10倍量水煎煮提取2次

每次 1.5 h;醇沉浓度60%;最佳制粒工艺为浸膏-糖粉-糊精1:2:1

临界相对湿度61%。结论: 优选的肠炎颗粒工艺稳定可行

可应用于其工业化生产。

Abstract

Objective:To optimize preparation technology of Changyan granule

and investigate its precipitation and molding technology. Method: Taking composite score of dry extract rate and berberine hydrochloride content as an indicator

orthogonal test was used to optimize extraction technology of Changyan granule with extraction time

extraction times and the amount of water as factors;Its precipitation technology was investigated by single factor test;With granule formability

mobility

hygroscopicity and pelletization as indexes

kinds of accessories were selected

and to determine the best moulding technology. Result: Optimum extraction technology was as following: decoction extracted 2 times with 10 times the amount of water

1.5 h per time;The concentration of alcohol precipitation of 60%;Optimal granulation technology was as following:the ratio of extract-icing sugar-dextrin 1: 2: 1

the critical relative humidity of61%. Conclusion: Optimized technologies of Changyan granule was stable and feasible

it could be applied to industrial production.

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Related Institution

Gansu Province Hospital of Traditional Chinese Medicine

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Beijing Key Laboratory of Chinese Materia Pharmacology，Institute of Basic Medical Sciences， Xiyuan Hospital，China Academy of Chinese Medical Sciences

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