Objective:To explore the dose-effect relationship among different ratio of Zexie decoction(ZD) on phlegm vertigo. Method: By feeding high fat diet and neck injection of sclerosing agent the phlegm vertigo model was established

according to the principle of uniform design 48 rabbits were divided into normal group

model group

ZD of 3 different ratio groups and flunarizine group

8 rats in each group

ratio of ZD was matched with groups respectively according to the 5∶2 (Zexie 50 g

Baizhu 20 g) 1∶1 (Zexie 20 g

baizhu 20 g)

1∶1 (Zexie 35 g

Baizhu 35 g) prescription medication

which were rally given for 2 weeks

10 weeks respectively after observation of tongue fur

nystagmus duration and carotid artery hemodynamics. Result: The weight in model group increased significantly compared with in the normal group(P<0.01)

appeared thick and greasy fur

nystagmus duration was significantly longer (P<0.01). Compared with the model group

cholesterol total(TC) of match group 2

decreased low density lipoprotein(LDL-C) level (P<0.05) and glycerin trilaurate(TG) level had more obvious difference (P<0.01); in match group 1 and 3 group TG

TC

LDL-C levels had significant differences (P<0.01). And the ratio of the two groups was compared

match group 1 and 3 group TG

LDL-C level was statistically different (P<0.05

P<0.01). Systolic flow velocity(Vs)

diastolic flow velocity(Vd) and the average flow velocity(Vm) of Left vertebral artery(LVA) in match group 3 were faster than those in the model group (P<0.05)

speed up its Vs

Vd and Vm of right vertebral artery(RVA) than those in the model group (P<0.01)

significantly speeding up basilar artery(BA) velocity of the systolic wave (Vs)

diastolic peak velocity (Vd) and mean peak velocity (Vm) than those in the model group (P<0.05 or 0.01) was accelerated apparently. And flunarizine group

3 groups of experimental animal ratio of RVA

BA Vd have markedly were vaccelerated(P<0.05). Conclusion: ZD with different ratio can regulate lipid metabolism

improve nystagmus symptoms of vertigo model

1∶1 (Zexie 35 g

Baizhu 35 g) ratiohas a better effect.