Pharmacokinetics of ZhiBing In-Situ Gel in Rabbits

DONG Fu-rong; ZHU Hong-xia; LIU Li; CHEN Zhi-liang; LIU Qiang

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Pharmacokinetics of ZhiBing In-Situ Gel in Rabbits

更新时间：2024-01-04

- Pharmacokinetics of ZhiBing In-Situ Gel in Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 2, Pages: 144-147(2013)
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- Published：2013
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DONG Fu-rong, ZHU Hong-xia, LIU Li, et al. Pharmacokinetics of ZhiBing In-Situ Gel in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 144-147.
DOI：

DONG Fu-rong, ZHU Hong-xia, LIU Li, et al. Pharmacokinetics of ZhiBing In-Situ Gel in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 144-147. DOI：

摘要

目的: 研究芷冰原位凝胶(ZB-ISG)在体内的吸收、分布及消除过程。方法: 选择新西兰大白兔为受试动物

以口服芷冰药液作为参比制剂

采用双周期两制剂交叉试验法

通过测定血清中欧前胡素的含量评价其体内的生物利用度。结果: 芷冰药液和ZB-ISG的AUC分别为(610.89±36.09)

(1150.77±64.61) μg·h·L-1

表明ZB-ISG在兔体内的吸收程度>芷冰药液;芷冰药液和ZB-ISG的Cmax分别为(62.7±7.71)

(110.7±10.76) μg·L-1

芷冰药液和ZB-ISG的tmax分别为(3.35±0.36)

(0.82±0.22) h

表明ZB-ISG经鼻腔给药欧前胡素的吸收量和吸收速率均>口服芷冰药液。结论: ZB-ISG相对于口服芷冰药液大大提高了欧前胡素的生物利用度。

Abstract

Objective: To investigate absorption

distribution and elimination process of ZB-ISG in rabbits. Method: Study on pharmacokinetics of ZB-ISG and oral Zhibing solution (reference preparation) by double preparation and double-period method in New Zealand white rabbits

in vivo bioavailability of ZB-ISG was evaluated by determining the content of imperatorin in serum. Result: AUC of Zhibing solution and ZB-ISG were (610.89±36.09)

(1 150.77±64.6 1) μg· h· L-1

respectively

it showed that absorption degree of ZB-ISG in rabbits was higher than Zhibing solution.Cmax of Zhibing solution and ZB-ISG were (62.7±7.71)

(110.7±10.76) μg· L-1

respectively

tmax of Zhibing solution and ZB-ISG were (3.35±0.36)

(0.82±0.22) h

respectively

these showed that absorption amount and rate of imperatorin after nasal administration of ZB-ISG were higher than oral Zhibing solution. Conclusion: Comparing with oral Zhibing solution

ZB-ISG could greatly enhance bioavailability of imperatorin in rabbits.

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Related Institution

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