Euphorbia Fischeriana Plyosaccharide Regulates Immune Function in S180 Tumor-bearing Mice

CUI Li-ran; XU Hao; LIU Ji-cheng; SUN Yong-xu; JIANG Li-yan

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Euphorbia Fischeriana Plyosaccharide Regulates Immune Function in S180 Tumor-bearing Mice

更新时间：2024-01-04

- Euphorbia Fischeriana Plyosaccharide Regulates Immune Function in S180 Tumor-bearing Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 2, Pages: 255-258(2013)
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- Published：2013
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CUI Li-ran, XU Hao, LIU Ji-cheng, et al. Euphorbia Fischeriana Plyosaccharide Regulates Immune Function in S180 Tumor-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 255-258.
DOI：

CUI Li-ran, XU Hao, LIU Ji-cheng, et al. Euphorbia Fischeriana Plyosaccharide Regulates Immune Function in S180 Tumor-bearing Mice[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 255-258. DOI：

摘要

目的: 观察狼毒多糖(EFP-AW1)对S180荷瘤鼠免疫逃逸功能的影响。方法: 将50只雄性ICR小鼠随机分为空白对照组、模型组、狼毒多糖100 mg·kg-1组、环磷酰胺100 mg·kg-1组(CTX)、联合给药组(EFP-AW1+CTX)。分组给药10 d后

通过噻唑蓝(MTT) 、酶联免疫吸附实验(ELISA) 、流式细胞术(FCM)之方法

检测荷瘤鼠脾淋巴细胞增殖情况、转化生长因子β1(TGF-β1) 、T淋巴细胞亚群(CD4+T

CD8+T)表达。结果: 狼毒多糖可增加刀豆蛋白A(ConA)/脂多糖(LPS)诱导的荷瘤鼠脾淋巴细胞增殖能力(P<0.05)

降低血清中TGF-β1的分泌(P<0.05)

增加CD8+T细胞百分含量(P<0.05)。结论: ESP-AW1可通过增强荷瘤鼠抗肿瘤免疫应答功能

抑制肿瘤细胞在体内转移和复发。

Abstract

Objective: To observe euphorbia fischeriana plyosaccharide (EFP-AW1) regulate the effect of immunologic function in S180 tumor-bearing mice. Method: Fifty male institute of lancer research(ICR) mice were randomly divided into 5 groups: control group

model group

EFP-AW1 group

CTX group

EFP-AW1 and CTX group. The mice were grouped and treated for 10 days by EFP-AW1.The splenocyte proliferation was measured by MTT in order to assess the effects on the immune activity by EFP-AW1; transforming growth factor(TGF-β1) determination by enzyme linked immunosorbent assay(ELISA); CD4+T

CD8+T tumor detected by flow cytometry in peripheral blood. Result: EFP-AW1 could significantly enhance ConA/LPS-induced T lymphocyte proliferation

and reduce TGF-β1 secretion

and increase the number of CD8+T lymphocytes in peripheral blood. Conclusion: EFP-AW1 can enhance immune response function in S180 tumor-bearing mice

inhibit tumor cell in vivo metastasis and recurrence.

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