Optimization of Extracting Technology of Costunolide and Dehydrocostus Lactone from

ZHOU Guang-tao; GAO Peng; DAI Bing; DAI Long

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Optimization of Extracting Technology of Costunolide and Dehydrocostus Lactone from

更新时间：2024-01-04

- Optimization of Extracting Technology of Costunolide and Dehydrocostus Lactone from
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 2, Pages: 40-42(2013)
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- Published：2013
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ZHOU Guang-tao, GAO Peng, DAI Bing, et al. Optimization of Extracting Technology of Costunolide and Dehydrocostus Lactone from [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 40-42.
DOI：

ZHOU Guang-tao, GAO Peng, DAI Bing, et al. Optimization of Extracting Technology of Costunolide and Dehydrocostus Lactone from [J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 40-42. DOI：

摘要

目的: 优选木香中去氢木香内酯和木香烃内酯的提取工艺。方法: 以木香烃内酯和去氢木香内酯提取率为指标

采用单因素试验考察提取方法;以木香烃内酯和去氢木香内酯提取率为指标

选取乙醇体积分数、料液比、提取时间及提取次数为考察因素

通过正交试验优选2种内酯的提取工艺。结果: 最佳提取工艺为采用乙醇温浸法

加6倍量90%乙醇于40℃温浸提取2次

每次2 h。木香烃内酯提取率92.3%

去氢木香内酯提取率94.1%

得膏率12.7%。结论: 优选的提取工艺稳定可行

木香中2种内酯的提取率高

适用于工业大生产。

Abstract

Objective: To optimize extracting technology of costunolide and dehydrocostus lactone from Aucklandia lappa. Method: With extraction rate of costunolide and dehydrocostus as indexes

extraction method was screened by single factor test;With extraction rate of costunolide and dehydrocostus as indexes

orthogonal test was used to evaluate effect of 4 factors on extracting technology

including solid-liquid ratio

the concentration of ethanol

extraction time and times. Result: The best extraction method was ethanol warm immersion method

optimum extracting technology was as follows:warm immersion extracted 2 times with 6 times the amount of 90% ethanol

respectively

extraction time of 2 hours.Extraction rate of costunolide and dehydrocostus lactone were 92.3

94.1%

respectively

and extract yield was12.7%. Conclusion: This optimized extracting technology was stable and feasible with high extraction rate of two kinds lactone from A. lappa

it was suitable for industrial production.

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Related Author

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Xiao-yan LIU

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Ai-ling SUN

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Related Institution

School of Chemistry and Chemical Engineering, Liaocheng University

School of Pharmacy,Liaoning University of Traditional Chinese Medicine

Tianjin Nankai Hospital

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Research Institute of Beijing Tongrentang Co. Ltd.

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