Protective Effect of Baicalin on Acute Lung Injury Rats Induced with Lipopolysaccharide
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Protective Effect of Baicalin on Acute Lung Injury Rats Induced with Lipopolysaccharide
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 3, Pages: 238-240(2013)
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Published:2013
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PAN Yong-li. Protective Effect of Baicalin on Acute Lung Injury Rats Induced with Lipopolysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 238-240.
DOI:
PAN Yong-li. Protective Effect of Baicalin on Acute Lung Injury Rats Induced with Lipopolysaccharide[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(3): 238-240.DOI:
Protective Effect of Baicalin on Acute Lung Injury Rats Induced with Lipopolysaccharide
Objective:To investigate the protective effect of baicalin on acute lung injury(ALI) rats induced with lipopolysaccharide (LPS). Method: SD rats were randomly divided into 6 groups (n=10): control
ALI model
dexamethasone (5 mg·kg-1) and baicalin groups (50
100
200 mg·kg-1). After 1 h of the last administration
the model of ALI was established by intratracheal instillation of LPS. After 6 h of the LPS instillation
the serum was collected for determinating the interleukin (IL) -1β
IL-8 and tumor necrosis factor (TNF) -α levels. In addition
the ratios of lung wet to dry weight and water content were also measured. The activity of myeloperoxidase (MPO) and cyclooxygenase (COX) -2 in lung was determinated. Result: Compared with control group
ALI group exhibited a higher wet to dry radio and water content in lung (P<0.05). Compared with ALI model group
baicalin significantly decreased the levels of IL-1β
IL-8 and TNF-α in serum (P<0.05)
reduced the wet to dry ratio and water content in a dose-dependent manner (P<0.05). Moreover
baicalin significantly decreased the activity of MPO and COX-2 in lung (P<0.05). Conclusion: Baicalin had a protective effect on ALI rats induced with LPS and the mechanism maybe related to the suppression of inflammation.