Antioxidative Effects  of Polysaccharides in and its Derivatives

ZHAO Yong-an; CHEN Guan; TAO Zun-wei

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Antioxidative Effects of Polysaccharides in and its Derivatives

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- Antioxidative Effects of Polysaccharides in and its Derivatives
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 229-232(2013)
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- Published：2013
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ZHAO Yong-an, CHEN Guan, TAO Zun-wei. Antioxidative Effects of Polysaccharides in and its Derivatives[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 229-232.
DOI：

ZHAO Yong-an, CHEN Guan, TAO Zun-wei. Antioxidative Effects of Polysaccharides in and its Derivatives[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 229-232. DOI：

摘要

目的: 对苦豆子多糖及其衍生物的体外抗氧化活性进行了研究。方法: 将苦豆子多糖硫酸化、磷酸化修饰后

以维生素C(VC)为对照

分别测定苦豆子多糖(SAP)、硫酸化苦豆子多糖(SAPS)和磷酸化苦豆子多糖(SAPP)3种多糖对二苯代苦味酰自由基(DPPH)、羟自由基(·OH)、超氧自由基(O2-·)的体外抗氧化活性及还原力。结果: SAPS和SAPP表现出不同程度抗氧化活性

并随浓度增加

活性增强

其中SAPS和SAPP清除DPPH 能力(IC50分别是4.573

6.542 mg·L-1)与SAP (IC5010.233 mg·L-1)相比

有显著提高;SAPP清除羟自由基(IC50 4.368 mg·L-1) 和SAPS清除超氧自由基(IC502.651 mg·L-1)能力显著提高。结论: 硫酸化和磷酸化修饰能提高苦豆子多糖的体外抗氧化活性。

Abstract

Objective:To investigate the antioxidant effect in vitro of polysaccharides in Sophora alopecuroides (SAP) and its derivatives. Method: After sulfation and phosphorylation of the SAP

the scavenging capacities of 1

1-diphenyl-2-picrylhydrazyl

superoxide anion radicals

hydroxyl free radicals and reducing power were assayed

with vitamin C(VC) as control. Result: The activity of modification products was increased with the concentration increasing. The scavenging rate against 1

1-dipheny 1.2-picrylhydmiyl DPPH 50% inhibition concentration (IC50

4.573 mg·L-1) and superoxide anion radicals IC50 2.651 mg·L-1 of SAPS were more than SAP. The scavenging rate against DPPH IC50

6.542 mg·L-1 and hydroxyl free radicals IC50 4.368 mg·L-1 of SAPP were more than SAP. Conclusion: The antioxidant activity of polysaccharides in S. alopecuroides can be improved through sulfation and phosphorylation of the SAP.

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Related Author

ZHAO Yong-an1

CHEN Guan2

TAO Zun-wei2

ZHANG Xiao-li

LI Kun

ZHANG Yan

ZHAO Zhen-yu

ZHANG Gui-xian

Related Institution

Tianjin Medical University

Tianjin Institute of Medical and Pharmaceutical Sciences

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