Objective:To study the protective effect of the Niuxin persimmon leaf polysaccharide on kidney injure in diabetic mice induced by streptozotocin(STZ) and its mechanisms. Method: Being established of diabetic mice model

the mice were randomly assigned to 5 groups: model group

melbinum group (0.32 g·kg-1)

low

medium and high-dose groups of Niuxin persimmon leaf polysaccharide (0.3

0.6

1.2 g·kg-1) for 15 consecutive days. At the end of 15 days

oxidase method was used to examine the blood glucose levels (fasting blood-glucose

FBG)

while the endpoint method was used to measured urinary albumin content (24 h). The changes in renal morphology were tested through HE-staining. The expressions of insulin-like growth factors-1(IGF-1) in renal tissue were determined using Western blot analysis. Result: Compared to model control group

Niuxin persimmon leaf polysaccharide could notably diminish the FBG in diabetic mice (P<0.05)

and measured urinary albumin content was reduced statistically (P<0.05). The IGF-1 protein level in renal tissue was up-regulated (P<0.05)

and the condition of renal injury alleviated finally. Conclusion: The results indicate that Niuxin persimmon leaf polysaccharide has protective effect on renal injury in diabetic mice induced by STZ. The mechanism may be related to inhibition of IGF-1 expression in renal tissue to regulate its downstream pathway.