Optimization of Preparation Technology of -Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule

SHI Ming-yi; LI Jian-li; XIE Yan; YANG Shan; XI Jian; WANG Li-jie

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Optimization of Preparation Technology of -Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule

更新时间：2024-01-04

- Optimization of Preparation Technology of -Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 1, Pages: 47-50(2013)
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- Published：2013
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SHI Ming-yi, LI Jian-li, XIE Yan, et al. Optimization of Preparation Technology of -Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 47-50.
DOI：

SHI Ming-yi, LI Jian-li, XIE Yan, et al. Optimization of Preparation Technology of -Cyclodextrin Inclusion Complexes for Volatile Oil in Guanxinkang Capsule[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 47-50. DOI：

摘要

目的: 优选β-环糊精包合冠心康胶囊挥发油的制备工艺

提高挥发油的稳定性。方法: 采用饱和水溶液超声法制备包合物

以挥发油包合率、包合物收得率及包合物含油率为综合评价指标

采用星点设计考察β-CD与挥发油的用量比、包合温度及超声时间等因素对包合工艺的影响

对结果进行多元线性回归和二项式拟合

用效应面法确定最佳工艺条件

并进行预测分析。结果: 冠心康胶囊挥发油的β-CD最佳包合工艺条件为β-CD与挥发油的用量比7:1

包合温度45℃

超声时间40 min

预测值与理论值偏差<3%。结论: 通过β-CD包合后可使挥发油粉末化

提高其稳定性。优选的包合工艺方法简便、预测性良好

为冠心康胶囊的工业生产提供试验依据。

Abstract

Objective:To grope preparation technology of β-cyclodextrin(β-CD) inclusion compound of volatile oil in Guanxinkang capsule

in order to improve stability of volatile oil. Method: Inclusion complexes was prepared by saturated aqueous solution ultrasonic method

with inclusion rate of volatile oil

inclusion oil content and inclusion yield as comprehensive evaluation index

influence of ratio of β-CD and volatile oil

inclusion temperature and ultrasonic time on inclusion technology was investigated by central composite design

test data was fitted by multi-linear regression and binomial equation

inclusion technology conditions were optimized by response surface method

and to predictive analysis. Result: Optimum inclusion process conditions were as follows:ratio of β-CD and volatile oil of 7: 1

inclusion temperature at 45℃ and ultrasonic time of 40 min

deviation between observed and predicted values was less than 3%. Conclusion: Volatile oil was powdered and its stability had been increased after being included by β-CD.This optimized inclusion process was simple with high predictability

it could provide test basis for industrial production of Guanxinkang capsule.

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Related Author

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YANG Li-xin

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LI Xi-xiang

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Related Institution

Institute of Basic Theory,China Academy of Traditional Chinese Medicine

Institute of Chinese Materia Medica,China Academy of Traditional Chinese Medicine

State Key Laboratory of Southwestern Chinese Medicine Resources， Chengdu University of Traditional Chinese Medicine

College of Pharmacy， Heilongjiang University of Chinese Medicine

Basic Medical College， Heilongjiang University of Chinese Medicine

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