Objective:To study the anti-inflammatory effects of Jingxuening capsule-butyl alcohol extracts (JXN-C). Method: Male rats or mice were randomly divided into JXN-C high dosage and low dosage groups (9

4.5 g·kg-1)

positive control group (Hexadecadrol 3 mg·kg-1)

blank control group (N S part aeq).All rats were intragastric administrated. Carrageenan-induced foot swelling was determined via volume measurement method

and the joint swelling inhibition rate was calculated. Ear swelling degree and inhibitory rate was investigated in ear auricle swelling mice model induced by xylene then nitric oxide (NO) was detected. Mouse peritoneal capillary permeability increasing model was employed and the absorbance(A) value of celiac irrigating solution was detected to investigate the anti-Inflammatory effects of JXN-C. Result: JXN-C low dosage (4.5 g·kg-1) markedly inhibited carrageenan-induced toes swelling after administrating 120

180 min

toes swelling ratio were significantly lower than that of blank control group (P<0.05). JXN-C high dosage (9 g·kg-1) significantly reduced serum NO concentration in carrageenan treated rat (P<0.05). JXN-C markedly inhibited ear swelling

the ear swelling ratio was 52.12% and 45.56% respectively

which was significantly lower than that of blank control group

but JXN-C had no effect on acetic acid-induced mouse peritoneal capillary permeability. Conclusion: JXN-C posses potent anti-inflammatory effects

one of the mechanism in the inhibit inflammatory process induced by NO.