Effect of Dencichine Injection on Nervous System of SD Rats
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Effect of Dencichine Injection on Nervous System of SD Rats
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 1, Pages: 252-255(2013)
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Published:2013
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ZHAO Ri-qiu, SHU Bin, Lin Na, et al. Effect of Dencichine Injection on Nervous System of SD Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 252-255.
DOI:
ZHAO Ri-qiu, SHU Bin, Lin Na, et al. Effect of Dencichine Injection on Nervous System of SD Rats[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 252-255.DOI:
Effect of Dencichine Injection on Nervous System of SD Rats
Objective:To study the effect of dencichine injection on nervous system. Method: The rats were given drug by iv once daily for 7 consecutive days. The SD rats were divided into 4 groups randomly: normal saline(NS)group
the low dose group
middle dose group and high dose group
the effect of dencichine for injection on autonomic activities was observed after administration of 1
2 h
7 d and withdrawal of injection. The SD rats were divided into 5 groups randomly: normal saline (NS) group
the low dose group
middle dose group
high dose group and positive control group(7.5 mg·kg-1 Pentobarbital sodium)
the effect of dencichine for injection on concordant ability was observed after administration of 1 h
7 d and withdrawal of injection. Result: Dencichine injection at the dose of 135 mg·kg-1 reduced autonomic and concordant ability of rats
this phenomenon disappeared after stopping injecting drugs. Dencichine injection at the dose of 45 mg·kg-1 increased autonomic ability of rats
but the phenomenon disappeared soon
and the dose of 45 mg·kg-1 had no effect on the concordant ability. Dencichine for injection at the dose of 15 mg·kg-1 increase autonomic ability of rats in a short time after stopping injecting drugs
but it had no effect on the concordant ability. Conclusion: Dencichine injection at the dose of 135 mg·kg-1 has obvious effect on nervous system. Dencichine injection at the dose of 45 mg·kg-1 has excitatory effects on the nervous system in a short period of time. Dencichine for injection at the dose of 15 mg·kg-1 have no effect on the nervous system
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