The Protective Effect of Acanthoic Acid on Liver Injury in Mice

HAO Cheng-yi; BAI Ting; NAN Ji-xing; LIAN Li-hua

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The Protective Effect of Acanthoic Acid on Liver Injury in Mice

更新时间：2024-01-04

- The Protective Effect of Acanthoic Acid on Liver Injury in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 24, Pages: 198-200(2012)
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- Published：2012
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HAO Cheng-yi, BAI Ting, NAN Ji-xing, et al. The Protective Effect of Acanthoic Acid on Liver Injury in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 198-200.
DOI：

HAO Cheng-yi, BAI Ting, NAN Ji-xing, et al. The Protective Effect of Acanthoic Acid on Liver Injury in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(24): 198-200. DOI：

摘要

目的: 探讨刺五加酸(AA)对小鼠急性肝损伤的保护作用。方法: 将60只小鼠随机分成6组

即正常组

乙醇模型组

水飞蓟素组(100 mg·kg-1)

刺五加酸高、中、低剂量组(30

5 mg·kg-1)。小鼠每隔12 h给药1次

连续给药3次。每次给药后1 h

除正常组外均灌胃60%乙醇(5 g·kg-1)。观察大鼠血清的生化指标和病理组织变化。结果: 在AA的高、中剂量组ALT(25±6)

(31±8)U·L-1

AST(157±23)

(187±18) U·L-1

TNF-α(32±4.62)

(41±5.3) μg·L-1以及TG(190±23)

(257±23) mmol·L-1明显下降

与模型组比较有显著性差异(P<0.001)

减少了肝损伤程度。结论: 刺五加酸对乙醇引起的小鼠急性肝损伤具有良好的保护作用。

Abstract

Objective:To study the protective effects of acanthoic acid (AA) against acute liver injury. Method: Sixty mice were andomly divided into six groups: the normal group

the ethanol model group

silymarin group (100 mg·kg-1)

high-dose AA group (30 mg·kg-1)

middle-dose AA group (10 mg·kg-1) and low-dose AA group (5 mg·kg-1). Each group received medicine by gavage every 12 hrs for a total of 3 doses.Except for normal group

the other mice were received 60% ethanol (5 g·kg-1) 1 h. After administrayion. The thehepatic pathological and biochemical index changes in rats were observed. Result: The high-dose AA group and the middle-dose AA group can reduce the level of ALT(25±6)

(31±8) U·L-1

AST(157±23)

(187±18) U·L-1

TNF-α(32±4.62)

(41±5.3) μg·L-1 and TG(190±23)

(257±23) mmol·L-1

which was compared with the model group

and showed a significant difference(P<0.001). Conclusion: The AA could protect mice from ethanol induced acute liver injury efficiently.

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Related Institution

School of Clinical Medicine，Changchun University of Chinese Medicine

School of Pharmacy，Changchun University of Chinese Medicine

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Dongzhimen Hospital， Beijing University of Chinese Medicine

College of Acupuncture and Moxibustion,Fujian University of TCM

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