Effect of Xinkai kujiang Formula Granules on Insulin Sensitivity in KKay Type 2 Diabetic Mice

LIU Hong-fang; HU Zhao-juan; ZHANG Yan-hong; GUO Hui-xia

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Effect of Xinkai kujiang Formula Granules on Insulin Sensitivity in KKay Type 2 Diabetic Mice

更新时间：2024-01-04

- Effect of Xinkai kujiang Formula Granules on Insulin Sensitivity in KKay Type 2 Diabetic Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 23, Pages: 233-237(2012)
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- Published：2012
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LIU Hong-fang, HU Zhao-juan, ZHANG Yan-hong, et al. Effect of Xinkai kujiang Formula Granules on Insulin Sensitivity in KKay Type 2 Diabetic Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 233-237.
DOI：

LIU Hong-fang, HU Zhao-juan, ZHANG Yan-hong, et al. Effect of Xinkai kujiang Formula Granules on Insulin Sensitivity in KKay Type 2 Diabetic Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 233-237. DOI：

摘要

目的: 运用转基因Kkay2型糖尿病小鼠为模型

观察用辛开苦降法传统煎剂(辛开苦降第1组)、辛开苦降法颗粒剂(辛开苦降第2组)干预对Kkay 2型糖尿病小鼠胰岛素敏感性及血脂的疗效。方法: 10周龄雄性初发2型糖尿病KKay小鼠36只按血糖值随机分为4组:模型组、罗格列酮组(0.67 g·kg-1·d-1)、辛开苦降煎剂组(8.7 g·kg-1·d-1)、辛开苦降颗粒剂(8.7 g·kg-1·d-1)。每天灌胃给药1次

4周后测定血糖、空腹血糖、胰岛素、血脂

计算胰岛素敏感指数。结果: 给药4周后

与正常组相比

模型组胰岛素敏感指数明显降低(P<0.01)

空腹血糖、甘油三酯、总胆固醇等明显升高。辛开苦降煎剂、辛开苦降颗粒剂与模型组相比

胰岛素敏感指数高于模型组(P<0.01)

空腹血糖值低于模型组(P<0.01);甘油三酯、总胆固醇均低于模型组

辛开苦降传统煎剂和辛开苦降法颗粒剂之间并无差异。结论: 辛开苦降法可改善初发2型糖尿病KKay小鼠的胰岛素抵抗

增加胰岛素的敏感性从而改善血糖水平

并能降低血脂水平

且煎剂和颗粒剂疗效相当。

Abstract

Objective: Using genetically modified Kkay type 2 diabetic mice as the model

to observe the effect of Xinkaikujiang traditional decoction (XKKJ-group 1) and Xinkaikujiang Formula granules (XKKJ-group 2) for insulin sensitivity and blood lipids in KKay type 2 diabetic mice. Method: According to the blood sugar

thirty-six male KKay mice (10 weeks old) were randomly divided into 4 groups

including the model group

the rosiglitazone group (0.67 g·kg-1·d-1)

the XKKJ-group 1 and the XKKJ-group 2 (8.7 g·kg-1·d-1). The control group was consisted of 9 C57BL/6J male mice(10 weeks old). The treatment groups were administered orally once a day

and both the control group and model group were given 0.5% sodium carboxymethylcellulose (CMC) solution. After 4-week treatment

the random blood sugar

fasting blood sugar (FBG)

serum insulin and blood lipids were determined

and the insulin sensitivity index was calculated. Result: After 4-week treatment

compared with the control group

the model group's ISI was significantly lowered(P<0.01)

FBG

triglyceride (TG) and total cholesterol (TC) were increased significantly(P<0.01). Compared with the model group

ISI in XKKJ-group 1 and XKKJ-group 2 was significantly improved (P<0.01)

FBG significantly lowered(P<0.01)TG and TC lowed. There were no difference between XKKJ-group 1 and XKKJ-group 2. Conclusion: The Chinese medicine of XKKJ could improve the insulin resistance in KKay type 2 diabetes mice

increase insulin sensitivity and rnduce the blood sugar level

lipid levels. The efficacy is not related to the dosage form.

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