Optimization of Preparation Technology of Extract Sustained-Release Microsphere by Orthogonal Test
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Optimization of Preparation Technology of Extract Sustained-Release Microsphere by Orthogonal Test
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 2, Pages: 32-34(2013)
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Published:2013
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WANG Yang, JIAO Hai-sheng. Optimization of Preparation Technology of Extract Sustained-Release Microsphere by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 32-34.
DOI:
WANG Yang, JIAO Hai-sheng. Optimization of Preparation Technology of Extract Sustained-Release Microsphere by Orthogonal Test[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 32-34.DOI:
Optimization of Preparation Technology of Extract Sustained-Release Microsphere by Orthogonal Test
Objective: To optimize preparation technology of Acanthopanax senticosus extract sustained-release microsphere. Method: With comprehensive scoring of drug-loading and entrapment efficiency as index
orthogonal test was used to investigate influence of four main factors on preparation technology
including the mass fraction of sodium alginate and CaCl2
A. senticosus extract-sodium alginate and cross-linking time. Result: Optimum Preparation technology was:the mass fraction of sodium alginate 3.5%
A. senticosus extract-sodium alginate 1:1
cross-linking time 2 h
the mass fraction of CaCl2 4.0%
drug loading and entrapment efficiency of prepared microsphere were10.11%
21.74%
respectively.Prepared A. senticosus extract sustained-release microsphere was dark brown and roundness
particle size was about 0.45 mm
cumulative release was up to 96.12% in 12 h. Conclusion: Optimized preparation technology was simple and reliable.