Effects of Jiangzhi Ⅱ Preparation on Experimental Hyperlipemia and Atherosclerosis in Rabbits

WANG Lin; WU Ji-kai; ZHU Ying; FAN Gan-bin

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Effects of Jiangzhi Ⅱ Preparation on Experimental Hyperlipemia and Atherosclerosis in Rabbits

更新时间：2024-01-04

- Effects of Jiangzhi Ⅱ Preparation on Experimental Hyperlipemia and Atherosclerosis in Rabbits
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 23, Pages: 230-233(2012)
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- Published：2012
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WANG Lin, WU Ji-kai, ZHU Ying, et al. Effects of Jiangzhi Ⅱ Preparation on Experimental Hyperlipemia and Atherosclerosis in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 230-233.
DOI：

WANG Lin, WU Ji-kai, ZHU Ying, et al. Effects of Jiangzhi Ⅱ Preparation on Experimental Hyperlipemia and Atherosclerosis in Rabbits[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 230-233. DOI：

摘要

目的: 探讨降脂Ⅱ制剂对实验性高脂血症家兔的降脂及抗动脉粥样硬化作用。方法: 采用高脂饲料喂养家兔建立高脂血症和动脉粥样硬化模型

分为对照组、模型组、辛伐他汀组(2.2 mg·kg-1) 、降脂Ⅱ制剂高、中、低剂量组(生药量4.6

2.3

1.2 g·kg-1)

ig 给药

每日1次。给药8周后测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、一氧化氮(NO)和内皮素-1(ET-1)含量;取主动脉

观察动脉斑块面积并进行病理学检查。结果: 降脂Ⅱ制剂可明显降低血清 TC

LDL

ET-1含量(P<0.05

0.01)

提高HDL

NO含量(P<0.05

P<0.01)

缩小斑块面积、减轻动脉粥样硬化程度。结论: 降脂Ⅱ制剂对家兔实验性高脂血症及动脉粥样硬化具有明显的抑制作用。

Abstract

Objective: To study the effects of Jiangzhi Ⅱ Preparation on experimental hyperlipemia and atherogensis in rabbits. Method: The hyperlipemia and atherosclerosis model in rabbits was established by feeding high-fat diet. All animals were randomly divided into normal group

model group

simvastatin group

Jiangzhi Ⅱ high

middle and low dose groups (4.6

2.3

1.2 g·kg-1).After eight weeks of treatment

the content of total cholesterol(TC)

triglyceride(TG)

low density lipoprotein(LDL)

high density lipoprotein(HDL)

nitric oxide(NO) and endothelin (ET-1) in serum were determined. The extent of aortic atherosclerosis was observed and the pathological examination was done. Result: In the Jiangzhi Ⅱ treatment groups

the concentration of TC

LDL

ET-1 in serum was decreased markedly

the concentration of HDL and NO was increased remarkably

the extent of aortic atherosclerosis and the atherosclerotic lesion were lightened obviously. Conclusion: Jiangzhi Ⅱ Preparation can effectively decrease the serum lipids and prevent the formation of atherosclerosis.

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TIAN Yingying

LI Yilin

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Related Institution

School of Chinese Materia Medica， Beijing University of Chinese Medicine

Institute of Scientific Research，Beijing Tongrentang Company Limited by Shares

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Key Laboratory of Basic and Applied Research on Northern Medicine， Ministry of Education， Experimental Teaching and Training Center， Heilongjiang University of Chinese Medicine

Department of Pharmacy,Beijing University of Chinese Medicine Dongzhimen Hospital

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