Effects of TSG on Expression of APP mRNA and PS1 mRNA in SAMP8 Mice

LIU Ling; ZHU Xiao-ying; LI Yun; LAI Shu; HUANG Zhong-shi

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Effects of TSG on Expression of APP mRNA and PS1 mRNA in SAMP8 Mice

更新时间：2024-01-04

- Effects of TSG on Expression of APP mRNA and PS1 mRNA in SAMP8 Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 1, Pages: 240-243(2013)
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- Published：2013
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LIU Ling, ZHU Xiao-ying, LI Yun, et al. Effects of TSG on Expression of APP mRNA and PS1 mRNA in SAMP8 Mice[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 240-243.
DOI：

LIU Ling, ZHU Xiao-ying, LI Yun, et al. Effects of TSG on Expression of APP mRNA and PS1 mRNA in SAMP8 Mice[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(1): 240-243. DOI：

摘要

目的: 探讨灌胃给二苯乙烯苷(TSG)后SAMP8小鼠β淀粉样蛋白前体(APP)mRNA和早老蛋白-1(PS1) mRNA表达的变化。方法: 6月龄快速老化模型小鼠SAMP8 50只

随机均分为SAMP8空白组

阳性药石杉碱甲对照组

高、中、低剂量TSG组(0.3

0.1

0.033 g·kg-1·d-1)共6组;6月龄正常老化小鼠SAMR1鼠10只为正常对照组。各组分别灌胃相应药物60 d后

应用实时定量PCR法检测海马组织APP 和早老蛋白-1(PS1)mRNA的表达。结果: 与SAMP8空白组比较

TSG组APP mRNA 2-△△CT值明显降低

PS1 mRNA 2-△△CT值也明显降低

差异具有统计学意义(P<0.05)

表明TSG组APP mRNA和PS1 mRNA表达下调。结论: 二苯乙烯苷对痴呆小鼠SAMP8有显著地抗痴呆作用

其作用机制可能与调控APP

PS1表达有关。

Abstract

Objective:To observe the effects of 2

4'-tetrahydroxy-stilbene-2-O-β-D-glycoside (TSG) on expression of β-amyloid precursor protein (APP) mRNA and presenilin-1(PS1) mRNA in senescence accelerated mouse (SAMP8). Method: Fifty six-month-old SAMP8 mice were randomized into 5 groups: SAMP8 untreated control group

huperzine A control group

low-

mid-and high-dose groups of TSG(0.033

0.1

0.3 g·kg-1·d-1)

with 10 mice in each group. Another ten 6-month-old SAMR1 mice were assigned to normal control group. After medication for 60 days

expression of APP and presenilin-1 (PS1) mRNA in hippocampus was assayed by real-time quantitative reverse transcription-PCR. Result: The expression of APP and PS1 mRNA in all dose of TSG groups was down-regulated. Compared with SAMP8 untreated control group

there was significant differences (P<0.05). Conclusion: TSG can inhibit the expression of APP mRNA in SAMP8 hippocampus

so as to play the role of anti-senile dementia.

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