Investigation of  Permeation of  Total Saponins Gel Ointments

WU Jing-lan; GUO Lu-mei; LIU Wen

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Investigation of Permeation of Total Saponins Gel Ointments

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- Investigation of Permeation of Total Saponins Gel Ointments
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 5, Pages: 17-20(2013)
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- Published：2013
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WU Jing-lan, GUO Lu-mei, LIU Wen. Investigation of Permeation of Total Saponins Gel Ointments[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 17-20.
DOI：

WU Jing-lan, GUO Lu-mei, LIU Wen. Investigation of Permeation of Total Saponins Gel Ointments[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(5): 17-20. DOI：

摘要

目的: 考察三七总皂苷凝胶膏剂的体外渗透性

优选透过介质和渗透促进剂。方法: 通过透皮扩散仪进行体外渗透试验

以三七皂苷R1

人参皂苷Rg1

人参皂苷Rb1含量为指标

研究三七总皂苷的体外渗透情况

采用HPLC检测三七总皂苷的透过量。结果: 选用硝酸纤维素膜作为透过介质

1%氮酮为渗透促进剂时

渗透效果最佳;三七总皂苷凝胶膏剂24 h累积透过量683.97 μg·cm-2

体外渗透符合Higuchi方程

渗透速率17.80 μg·cm-2·min-1。结论: 三七总皂苷凝胶膏剂具有较好的渗透性

适合作为三七总皂苷的新型透皮给药剂型。

Abstract

Objective:To investigate in vitro permeability of Panax notoginseng total saponins gel ointments

and optimize permeation medium and permeation enhancer. Method: With the total content of notoginsenoside R1

ginsenoside Rg1 and ginsenoside Rb1 as index

in vitro permeation of total saponins from P. notoginseng was detected by transdermal diffusion instrument

permeation amount of total saponins from P. notoginseng was determined by HPLC. Result: Penetration effect was the best with nitrocellulose membrane as permeation medium and azone as permeation enhancer;Accumulative permeation amount of P. notoginseng total saponins gel ointments in 24 h was 683.97 μg·cm-2

in vitro permeation could be described by model of Higuchi equation

and permeation rate was 17.80 μg·cm-2·min-1. Conclusion: P. notoginseng total saponins gel ointments had good permeability

it was suitable as a novel transdermal drug delivery formulation of total saponins from P. notoginseng.

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Related Author

WU Jing-lan

GUO Lu-mei

LIU Wen

SHENG Hua-gang1

QI Hong2

LIN Gui-tao1

ZHOU Li-ling

WU Yang

Related Institution

Guiyang College of Traditional Chinese Medicne

Shandong University of Traditional Chinese Medicine,Ji’nan

Department of Pharmaceutics,Guangzhou University of Chinese Medicine

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