Objective: To investigate physical characteristics of raw materials in Zhichan granules

and optimize prescription and molding technology of Zhichan granules. Method: Physical characteristics of raw materials in Zhichan granules were determined by powder comprehensive test instrument

laser particle size distribution instrument and so on

including water content

compression degree

angle of repose

et al;With forming rate

friability and appearance score as indexes

single factor and orthogonal test were used to select optimum accessory and granulation technology parameters of Zhichan granules. Result: Angle of repose of preparation materials was 31°

cohesion 1.36 kpa

compression degree 33.96%

water content 4.84%

particle size distribution 37.96 μm;Optimum prescription consisted of 84.0% extract powder

1.0% magnesium stearate

0.7%sucralose

0.5% black tea flavor

13.8% dextrin;Optimal dry granulation technology parameters were as follows:horizontal speed 30 r·min-1

roll wheel speed 5 r·min-1

roll wheel pressure 5 MPa. Conclusion: Study of physical property of preparation materials could guide screening prescription of dry granulation preparations;These prepared Zhichan grunules had high drug-loading and forming rate with good taste and appearance

this optimized dry granulation technology was stable and reasonable.