Effect of Paeoniflorin on Reserpine-induced Depression Model in Mice

CUI Guang-zhi; JIN Shu-mei

您当前的位置：

首页 >

文章列表页 >

Effect of Paeoniflorin on Reserpine-induced Depression Model in Mice

更新时间：2024-01-04

- Effect of Paeoniflorin on Reserpine-induced Depression Model in Mice
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 22, Pages: 272-274(2012)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2012
- 稿件说明：
移动端阅览
CUI Guang-zhi, JIN Shu-mei. Effect of Paeoniflorin on Reserpine-induced Depression Model in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 272-274.
DOI：

CUI Guang-zhi, JIN Shu-mei. Effect of Paeoniflorin on Reserpine-induced Depression Model in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 272-274. DOI：

摘要

目的: 研究芍药苷对利血平诱导小鼠抑郁模型的行为以及脑组织中单胺递质含量的影响。方法: 动物随机分为6组

即对照组、模型组、盐酸氯米帕明40 mg·kg-1组、芍药苷(50

100

200 mg·kg-1)组

均按10 mL·kg-1灌胃给药。每日1次

连续给药7 d

利用利血平诱导小鼠抑郁模型

观察芍药苷的抗抑郁作用。采用HPLC检测小鼠脑组织中单胺递质含量变化。结果: 芍药苷(100

200 mg·kg-1)连续灌胃给药7 d可显著提高小鼠抑郁模型体温(P<0.05

P<0.01)

芍药苷(200 mg·kg-1)可改善眼睑下垂(P<0.01)及运动不能(P<0.05);并可明显升高脑组织中去甲肾上腺素(NE)(P<0.01和P<0.001)和5-羟色胺(5-HT) (P<0.05

P<0.001)含量。结论: 芍药苷具有一定的抗抑郁作用

其机制可能与调节单胺递质含量有关。

Abstract

Objective:To investigate the effects of paeoniflorin on behavior and the brain tissue content of monoamine neurotransmitters in reserpine-induced depression model in mice. Method: The animals were randomly divided into 6 groups

namely the control group

model group

clomipramine(40 mg·kg-1) group and paeoniflorin (50

100

200 mg·kg-1) group. The drugs were given daily for 7 days. Reserpine-induced depression model was established to evaluate the antidepressant effect of paeoniflorin. The content of monoamine neurotransmitters in mice was measured by the HPLC. Result: Paeoniflorin(100

200 mg·kg-1

ig 7 day) could significantly increase the body temperature in mice model of depression(P<0.05

P<0.01)

improved ptosis (P<0.01)and activity inhibition(P<0.05)

significantly increased content of Norepinephrine(NE) (P<0.01

P<0.001)and 5-hydroxytryptamine(5-HT) (P<0.05

P<0.001)in mice. Conclusion: Paeoniflorin has remarkable antidepressant effects

its mechanism may be involved in monoaminergic nervous system.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Paeoniflorin Induces Apoptosis in NSCLC Cells via Activating Hippo Signaling Pathway

Protective Mechanism of Paeoniflorin on Mice with Ulcerative Colitis Based on AMPK/mTOR Autophagy Pathway

Chemical Constituents and Pharmacological Effects of Paeoniae Radix Rubra： A Review

Effect of Tianwang Buxin Pills on Behavior, HPA Axis, BDNF Expression and Phosphorylation of GSK3β in Mice with Chronic Unpredictable Stress

Analysis on Quality Transmitting of Substance Benchmarks of Shaoyao Gancaotang

Related Author

LI Yan

PENG Liang

JIANG Lifeng

WANG Sheng

WANG Ge

YU Xiaolin

YAO Yulin

DAI Xin

Related Institution

Henan University of Chinese Medicine

Fuwai Central China Cardiovascular Hospital/Henan Provincial People's Hospital

The Affiliated Cancer Hospital of Zhengzhou University/Henan Cancer Hospital

School of Clinical Medicine，Changchun University of Chinese Medicine

School of Pharmacy，Changchun University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰