Experimental Treatment of Deduhonghua-7 Powder on CCl Induced Hepatic Fibrosis

BA Tu-de-li-gen; HAN Zhi-qiang; NA Ri-su; QING Yu; MU Qi

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Experimental Treatment of Deduhonghua-7 Powder on CCl Induced Hepatic Fibrosis

更新时间：2024-01-04

- Experimental Treatment of Deduhonghua-7 Powder on CCl Induced Hepatic Fibrosis
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 18, Issue 22, Pages: 267-272(2012)
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- Published：2012
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BA Tu-de-li-gen, HAN Zhi-qiang, NA Ri-su, et al. Experimental Treatment of Deduhonghua-7 Powder on CCl Induced Hepatic Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 267-272.
DOI：

BA Tu-de-li-gen, HAN Zhi-qiang, NA Ri-su, et al. Experimental Treatment of Deduhonghua-7 Powder on CCl Induced Hepatic Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(22): 267-272. DOI：

摘要

目的: 观察德都红花-7味散对四氯化碳(CCl4)所致大鼠肝纤维化的治疗作用。方法: 将大鼠按体重随机分为空白对照组、模型组、秋水仙碱组、德都红花-7味散组。除空白对照组

其他组ip 30% CCl4橄榄油溶液诱导大鼠肝纤维化。造模同时德都红花-7味散组和秋水仙碱组分别 ig 德都红花-7味散和秋水仙碱每日0.62 g·kg-1 和0.4 mg·kg-1

连续7周。观察肝脏系数、肝功能、纤维4项

用HE

Gomori

Masson 3种方法染色

观察肝组织病理学改变。结果: 与空白对照组比较

模型组丙氨酸氨基转氨酶(ALT)、白蛋白(Alb)、总蛋白(TP)、总胆红素(TBIL)、碱性磷酸酶(ALP)等

肝脏指数、血清及肝组织匀浆纤维4项明显升高

Alb和体重降低

P＜0.05。与模型组比较

德都红花-7味散组AST

ALT

ALP

肝脏指数

肝组织匀浆Hyp

血清和肝组织纤维4项明显降低

Alb升高

秋水仙碱组ALT

AST

ALP

BIL降低

肝组织HA升高

Ⅳ降低(P＜0.05)。与秋水仙碱组比较德都红花-7味散组Alb含量升高

血清HA

LN含量降低

肝组织HA

ⅣC

Hyp含量降低(P＜0.05)。结论: 德都红花-7味散有较好的降酶保肝、抗肝纤维化作用。

Abstract

Objective:To observe the treatment of Deduhonghua-7 Powder on rat with carbon tetrachloride(CCl4) induced hepatic fibrosis. Method: Rats were randomly divided into normal control group

model group

Colchicine group and Deduhonghua-7 powder group. Except the normal control group

other groups were caused hepatic fibrosis by ip 30% CCl4 solution of olive oil. Modeling the same time

the rats in Deduhonghua-7 powder group and Colchicine group were ig 0.62 g·kg-1 and 0.4 mg·kg-1 each day of Deduhonghua-7 powder and Colchine respectively

continued for 7 days. Liver indexes

liver function

fibrosis four projects were observed

pathological changes in liver tissues were evaluated by HE

Gomori

Masson stainings. Result: Comparing with normal control group

aspartate transaminase(AST)

alanine transpeptidase(ALT)

alkaline phosphatase(ALP)

total protein(TP)

total bilirubin(TBIL)

liver indexes

fibrosis four projects of serum and liver tissues homogenates were significantly increased

albumin(Alb)

and bodyweight were decreased in the model group (P<0.05). Comparing with model group

in the Deduhonghua-7 Powder group

AST

ALT

ALP

liver indexes

liver tissues homogenates Hyp

serum and liver tissues fibrosis four projects were significantly decreased

Alb was increased; and in the Colchine group

ALT

AST

ALP

BIL were decreased

liver tissues hyaluronic acid(HA) was increased

IV was decreased (P<0.05). Comparing with Colchine group

Deduhonghua-7 Powder group’s Alb was increased

serum HA

LN contents were decreased

liver tissues HA

IV-C

Hyp contents were decreased (P<0.05). Conclusion: Deduhonghua-7 Powder showed good effect on reducing enzyme

protecting liver and anti-fibrosis for liver.

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