Metabonomics Study on the Serum Amino Acid in Type 2 Diabetes Mice Treated by Extract of
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Metabonomics Study on the Serum Amino Acid in Type 2 Diabetes Mice Treated by Extract of
Chinese Journal of Experimental Traditional Medical FormulaeVol. 18, Issue 23, Pages: 220-224(2012)
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Published:2012
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HAN Xue, MA Xiao-li, LI Lin-lin, et al. Metabonomics Study on the Serum Amino Acid in Type 2 Diabetes Mice Treated by Extract of[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 220-224.
DOI:
HAN Xue, MA Xiao-li, LI Lin-lin, et al. Metabonomics Study on the Serum Amino Acid in Type 2 Diabetes Mice Treated by Extract of[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(23): 220-224.DOI:
Metabonomics Study on the Serum Amino Acid in Type 2 Diabetes Mice Treated by Extract of
Objective: To investigate the serum amino acid variation in diabetic mice. Method: SPF mice were fed with high-fat diet for 4 weeks and then injected with streptozotocin(STZ). Mice were successively administrated with ethyl acetate extract Coreopsis tinctoria(8 g·kg-1·d-1) for 30 days. HPLC was used for the analysis of amino acid metabolites in serum samples. These data were analyzed by partial least square-discrimiant analysis (PLS-DA). Result: Compared with the control mice
the metabolism profiles of amino acid in the model mice were significantly different from that of the control mice. Pattern recognition method was applied and 4 amino acid markers were different between all the groups. Conclusion: The amino acid metabolism profiling may reflect to certain extent the pathological changes of type 2 diabetic mice. This work can provide basis for further researches on the interpretation of drug property of evidence.