Objective: To optimize preparation technology for Flow Yinpian of Cirsium setosum

and compare with traditional Yinpian of C. setosum. Method: With the mass fraction of linarin as index

orthogonal method was used to investigate influence of grinding degree

the amount of water

roll pill speed on preparation technology;TLC

HPLC

SD-IR were used to compare traditional Yinpian with Flow Yinpian of C. setosum. Result: Optimized preparation technology was as following:grinding degree 80 mesh

the amount of water 1.8 times

roll pill speed 300 r· min-1

mean particle size of prepared Flow Yinpian of (1.94±0.20) mm

roundness of 9.09-27.7

bulk density 0.394 3 g· cm-3

true density 0.655 7 g·cm-3

mean hardness 6.2 N

mean friability 0.30%.Their TLC were similar

the content of linarin was 0.64% in traditional Yinpian

while it was 0.72% in Flow Yinpian.Decoction curve of them was close

IR spectroscopy of their decoction was nearly the same. Conclusion: Traditional Yinpian and Flow Yinpian of C. setosum was reciprocity in pharmacy

they could substitute for each other.