Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line
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Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line
Chinese Journal of Experimental Traditional Medical FormulaeVol. 19, Issue 4, Pages: 212-215(2013)
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Published:2013
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LIUBAO Xin-zi, WANG Rui-ping, ZOU Xi, et al. Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 212-215.
DOI:
LIUBAO Xin-zi, WANG Rui-ping, ZOU Xi, et al. Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(4): 212-215.DOI:
Effect of Hederagenin on Biological Behaviors Including Proliferation,Adhesion, Invasion and Migration Capabilities of Human Gastric Cancer Cell Line
Objective: This study was designed to explore:the effect of hederagenin on the biological behaviors including proliferation
adhesion
invasion and migration capabilities of human gastric cancer cell line MGC-803 in vitro. Method: Using MTT
adhesion experiment
transwell room
wooding healing to observe the effect of hederagenin on the biological behaviors including proliferation
adhesion
invasion and migration capabilities. Result: ①Hederagnin significantly inhibited the proliferation of MGC-803 cells. (P<0.01)
the result showed that inhibition ratio increase with the increasing of the concentration of concentration and the passage of time. ② Hederagnin significantly decreased the adhesion capability of MGC-803 cells (P<0.01)
along with the increasing of the concentration and the passage of time
present the results of inhibition rate increasing. ③Hederagnin roled in human gastinc cancer cells MGC-803 so that the cell invasion number is significantly reduced (P<0.01)
the higher concentration
the less the number of cell invasion. ④After hederagnin roled in human gastric cancer cells MGC-803
cell healing degree have obvious group difference
the higher concentration
the worse of degree of healing
which showed that migration ability greatly affected. Conclusion: Hederagnin can inhibite the proliferation of human gastric cell line MGC-803 and supresse the adhesion
invasion and migration capability of MGC-803 cells.
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Related Author
Lian-hua HE
Yi-qun LI
Jing-xia WANG
Cong-cong SUN
Chun-fang LIU
Yu JING
Yan-dong MIAO
Na LIN
Related Institution
Institute of Chinese Materia Medica, China Academy of Chinese Medicine
Peking University Shenzhen Hospital
Tonghua Golden-horse Group
The First Affiliated Hospital of Nanchang University