Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88, TLR4 Receptor

ZHANG Lian; ZHOU Yu-ping; LIU Guang-wei

您当前的位置：

首页 >

文章列表页 >

Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88, TLR4 Receptor

更新时间：2024-01-04

- Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88, TLR4 Receptor
- Chinese Journal of Experimental Traditional Medical Formulae Vol. 19, Issue 2, Pages: 226-229(2013)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2013
- 稿件说明：
移动端阅览
ZHANG Lian, ZHOU Yu-ping, LIU Guang-wei. Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88, TLR4 Receptor[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 226-229.
DOI：

ZHANG Lian, ZHOU Yu-ping, LIU Guang-wei. Therapeutic Effects of Astragalus Saponin on Rats with Atrophic Gastritis and MyD88, TLR4 Receptor[J]. Chinese journal of experimental traditional medical formulae, 2013, 19(2): 226-229. DOI：

摘要

目的: 观察黄芪皂苷对萎缩性胃炎(CAG)大鼠的治疗作用

以及对髓样分化因子(MyD88)

Toll样受体4(TLR4)受体的影响。方法: 采用综合法造模

建立大鼠萎缩性胃炎模型

造模成功后

分别用生理盐水、黄芪皂苷(14.93 mg·kg-1)和硫糖铝(360 mg·kg-1)ig。在ig的10周、15周时分别处死大鼠

取大鼠全胃

取材、切片

HE染色

固定切片后

显微镜下观察有无肠上皮化生、假性幽门腺化生、不典型增生的发生情况

检测不同组别大鼠各期的胃组织中的MyD88

TLR4的表达

比较各组间MyD88

TLR4表达的差异

并检测血清中超氧化物歧化酶(SOD)活性

研究黄芪皂苷对萎缩性胃炎大鼠的治疗作用。结果: 黄芪皂苷对萎缩性胃炎大鼠具有治疗作用

黄芪皂苷治疗后

肠上皮化生、假性幽门腺化生、不典型增生的发生情况明显减少

同时MyD88

TLR4的表达较空白组、硫糖铝组明显降低

而SOD活性的表达以黄芪皂苷组较高

与空白组相近

其次为硫糖铝组。结论: 黄芪皂苷可以阻止MyD88

TLR4受体的激活

提高SOD活性

对于萎缩性胃炎具有治疗作用。

Abstract

Objective: To observe the therapeutic effects of astragalus saponin on rats with atrophic gastritis (CAG)

and on myeloid differentiation factor 88(MyD88)

Toll-like receptor 4(TLR4) receptor. Method: The rat model of atrophic gastritis was established with synthesis method.Then saline

astragalus saponin(14.93 mg·kg-1) and sucralfate(360 mg·kg-1)were given orally after the modeling rats were sacrificed after 10 weeks and 15 weeks

and whole stomach was collected to observe whether there were intestinal metaplasia

pseudo-pyloric metaplasia

atypical hyperplasia under the microscope

the expression of MyD88 and TLR4 was detected. Result: Astragalus saponin had a therapeutic effect on rats with atrophic gastritis

the occurrence of intestinal metaplasia

pseudo-pyloric metaplasia

atypical hyperplasia significantly reduced

at the same time

the expression of TLR4 and MyD88 decreased significantly compared with blank group and sucralfate group

higher expression of superoxide dismutase(SOD) activity in astragalus saponin group was found. Conclusion: Astragalus saponin can prevent the activation of MyD88

TLR4 receptors and improve the activity of SOD

it has a therapeutic effect on atrophic gastritis.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Effect and Mechanism of Wogonin on NF-B Nuclear Translocation and Expression in NR8383 Cells Infected by Influenza Virus

Effect of Shaohuang Anchang Decoction on TLR4/Myd88/NF-B Signaling Pathway in Ulcerative Colitis Rats

Effect and Mechanism of Wogonin on NF-κB Nuclear Translocation and Expression in NR8383 Cells Infected by Influenza Virus

Related Author

HAO Yu

ZHANG Jin

YAN Yue-jie

ZHANG Shu

JIN Ye-zhi

WU Ying

FAN Yao-fu

ZHANG Qian-de

Related Institution

Department of Microbiology and Immunology,Beijing University of Chinese Medicine

AI问答

Postal code：100700
Tel：010-84076882 Email：syfjx_2010@188.com
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备11006657号-10 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰